Zhiguo Ma

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Astrocytes associate with synapses throughout the brain and express receptors for neurotransmitters that can increase intracellular calcium (Ca2+). Astrocytic Ca2+ signalling has been proposed to modulate neural circuit activity, but the pathways that regulate these events are poorly defined and in vivo evidence linking changes in astrocyte Ca2+ levels to(More)
Ends-in and ends-out gene replacement approaches have been successfully used to disrupt Drosophila genes involved in a variety of biological processes. These methods combine double-strand breaks and homologous recombination to replace a targeted chromosome region with a designed DNA sequence. Unfortunately, these methods require large numbers of single(More)
Pain signaling in vertebrates is modulated by neuropeptides like Substance P (SP). To determine whether such modulation is conserved and potentially uncover novel interactions between nociceptive signaling pathways we examined SP/Tachykinin signaling in a Drosophila model of tissue damage-induced nociceptive hypersensitivity. Tissue-specific knockdowns and(More)
21 Pain signaling in vertebrates is modulated by neuropeptides like Substance P (SP). To 22 determine whether such modulation is conserved and potentially uncover novel interactions 23 between nociceptive signaling pathways we examined SP/Tachykinin signaling in a Drosophila 24 model of tissue damage-induced nociceptive hypersensitivity. Tissue-specific(More)
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