Zhigang Yan

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The ongoing avian H7N9 influenza outbreaks in China have caused significant human fatal cases and the virus is becoming established in poultry. Mutations with potential to increase mammalian adaptation have occurred in the polymerase basic protein 2 (PB2) and other viral genes. Here we found that dual 627K and 701N mutations could readily occur during(More)
BACKGROUND The prevalence of Helicobacter pylori is higher in developing countries. The aim of this study was to investigate the prevalence and risk factors of H. pylori infection in areas with high prevalence of gastric cancer in Jiangsu Province, China. METHODS A prospective epidemiologic survey of H. pylori infection was accomplished in a natural(More)
The transforming growth factor (TGF)-β is a potent growth inhibitor primarily responsible for cell growth, differentiation, and apoptosis, and frequently perturbed during development of tumors, including gastric cancer. TGF-β receptor type I (TGFβR1) may be a modifier of cancer risk by constitutively decreasing the TGF-β inhibitory signals during early(More)
Ultra high performance liquid chromatography (UHPLC) coupled with a hybrid quadrupole time-of-flight mass spectrometry (QTOF-MS) was used to separate and identify the compounds in Scutellaria indica L. Fragmentation patterns of these compounds were investigated by the UHPLC-QTOF-MS technique in both negative and positive ion modes. By using this strategy,(More)
Recent years, more and more cities have planned to build " digital city ". In which the city information and its services is the core of urban plan, construction and management. of all the city informations, the spatial information plays an important role, compared with the other informations,there are some specialities in the urban spatial information,(More)
Urban traffic tunnel is a new and effective urban transport mode. The operation managerial experience about urban traffic tunnel is deficient. According to the needs of urban traffic, this paper studied the structure of urban traffic tunnel and designed the safety evaluation index system of urban traffic tunnel. The safety evaluation index system considered(More)
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