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Error-free and error-prone lesion bypass by human DNA polymerase κ in vitro
Error-free lesion bypass and error-prone lesion bypass are important cellular responses to DNA damage during replication, both of which require a DNA polymerase (Pol). To identify lesion bypass DNAExpand
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Potential role of metabolomics apporoaches in the area of traditional Chinese medicine: as pillars of the bridge between Chinese and Western medicine.
Traditional Chinese medicine (TCM) is a holistic approach to health that attempts to bring the body, mind and spirit into harmony. Entering 21st century, TCM is getting more and more popular in theExpand
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Implication of DNA Polymerase λ in Alignment-based Gap Filling for Nonhomologous DNA End Joining in Human Nuclear Extracts*
Accurate repair of free radical-mediated DNA double-strand breaks by the nonhomologous end joining pathway requires replacement of fragmented nucleotides in the aligned ends by a gap-filling DNAExpand
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trans-Lesion Synthesis Past Bulky Benzo[a]pyrene Diol Epoxide N 2-dG and N 6-dA Lesions Catalyzed by DNA Bypass Polymerases*
The effectiveness of in vitro primer elongation reactions catalyzed by human bypass DNA polymerases κ (hDinB1), pol η (hRad30A), pol ι (hRad30B), and yeast pol ζ (Rev3 and Rev7) in site-specificallyExpand
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Response of human REV1 to different DNA damage: preferential dCMP insertion opposite the lesion.
REV1 functions in the DNA polymerase zeta mutagenesis pathway. To help understand the role of REV1 in lesion bypass, we have examined activities of purified human REV1 opposite various template basesExpand
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Superparamagnetic PLGA-iron oxide microcapsules for dual-modality US/MR imaging and high intensity focused US breast cancer ablation.
Organic/inorganic, hybrid, multifunctional, material-based platforms combine the merits of diverse functionalities of inorganic nanoparticles and the excellent biocompatibility of organic systems. InExpand
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Expression Profiling and Validation of Potential Reference Genes During Paralichthys olivaceus Embryogenesis
Differential expression of genes is crucial to embryogenesis. The analysis of gene expression requires appropriate references that should be minimally regulated during the embryonic development. ToExpand
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Role of DNA polymerase eta in the bypass of abasic sites in yeast cells.
Abasic (AP) sites are major DNA lesions and are highly mutagenic. AP site-induced mutagenesis largely depends on translesion synthesis. We have examined the role of DNA polymerase eta (Poleta) inExpand
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Antitumor Effect of Docetaxel‐Loaded Lipid Microbubbles Combined With Ultrasound‐Targeted Microbubble Activation on VX2 Rabbit Liver Tumors
Objective. The purpose of the study was to explore the antitumor effect of docetaxel‐loaded lipid microbubbles combined with ultrasound‐targeted microbubble activation (UTMA) on VX2 rabbit liverExpand
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Lesion bypass activities of human DNA polymerase mu.
DNA polymerase mu (Polmu) is a newly discovered member of the polymerase X family with unknown cellular function. The understanding of Polmu function should be facilitated by an understanding of itsExpand
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