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Formyl Peptide Receptor Suppresses Melanoma Development and Promotes NK Cell Migration
The FPR family promoted NK cell migration through ERK activation and inhibited B16 melanoma growth in a murine model. Expand
Effect of supplemetation of Zebularine and Scriptaid on efficiency of in vitro developmental competence of ovine somatic cell nuclear transferred embryos
This study proved that 5 nmol/L Zebularine and 0.2 μmol/L Scriptaid treating with sheep donor cumulus cells and reconstructed embryos improved SCNT blastocyst rate and relieve the abnormal expression of embryonic developmental related genes. Expand
Zebularine significantly improves the preimplantation development of ovine somatic cell nuclear transfer embryos.
- H. Cao, Jun Li, +10 authors Chuang Liu
- Biology, Medicine
- Reproduction, fertility, and development
- 21 January 2019
The results indicate that, in an ovine model, zebularine decreases overall DNA methylation levels in donor cumulus cells and reconstructed embryos, downregulates theDNA methylation profile in the promoter region of pluripotency genes in donor cells and ultimately elevates the expression of plurine genes in the reconstruct embryos, which can lead to improved development of SCNT embryos. Expand
Effects of TLR4 overexpression on sperm quality, seminal plasma biomarkers, sperm DNA methylation and pregnancy rate in sheep.
There was no evidence that TLR4 overexpression altered the sperm quality, seminal plasma or sperm DNA of transgenic sheep, and pregnancy rate was similar between these two groups. Expand