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CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancer
The study elucidates that fine tuning of HULC expression is part of an auto-regulatory loop in which it’s inhibitory to expression and activity of miR-372 allows lncRNA up-regulated expression in liver cancer.
NF-kappaB P50/P65 hetero-dimer mediates differential regulation of CD166/ALCAM expression via interaction with micoRNA-9 after serum deprivation, providing evidence for a novel negative…
A novel negative auto-regulatory loop in which NF-κB mediates differential regulation of CD166 after SD is elucidated and it is proposed that miR-9 promotes cell migration largely due to inhibition ofCD166.
Identification of novel mitosis regulators through data mining with human centromere/kinetochore proteins as group queries
- A. R. Tipton, Kexi Wang, Peter O. Oladimeji, S. Sufi, Zhidong Gu, Song-Tao Liu
- BiologyBMC Cell Biology
- 19 June 2012
Transcriptional co-expression and PPI network analyses with known human centromere/kinetochore proteins as a query group help identify novel potential mitosis regulators.
Establishment of High-Performance Liquid Chromatography and Enzyme Multiplied Immunoassay Technology Methods for Determination of Free Mycophenolic Acid and Its Application in Chinese Liver…
A considerable interindividual variability exists in pharmacokinetics of fMPA among Chinese liver transplant recipients and 7-O-Glucuronide conjugate of MPA and albumin concentrations are two factors correlated to fM PA variance.
SP1 plays a pivotal role for basal activity of TIGAR promoter in liver cancer cell lines
- Shubiao Zou, Zhidong Gu, Peihua Ni, Xiangfan Liu, Jiayi Wang, Qishi Fan
- BiologyMolecular and Cellular Biochemistry
Data from electrophoretic mobility shift assay and chromatin immunoprecipitation showed that SP1 can interact with the SP1-binding site within TIGar promoter in vitro and in vivo, and concluded that SPl is indispensable for basal activity of TIGAR promoter.
Population pharmacokinetic study of cyclosporine in Chinese renal transplant recipients
- Bing Chen, Wei-xia Zhang, Zhidong Gu, Juan Li, Yuxin Zhang, W. Cai
- Biology, MedicineEuropean Journal of Clinical Pharmacology
- 1 June 2011
The PPK model developed in this study could be used to optimize CsA dose for Chinese renal transplant recipients by using conventional therapeutic drug monitoring (TDM) data.
Models for the prediction of mycophenolic acid area under the curve using a limited-sampling strategy and an enzyme multiplied immunoassay technique in Chinese patients undergoing liver…
Synthesis of magnetic and fluorescent bifunctional nanocomposites and their applications in detection of lung cancer cells in humans.
SP1 is required for basal activation and chromatin accessibility of CD151 promoter in liver cancer cells.