Zhichao Yan

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Primary open angle glaucoma (POAG) is a neurodegenerative disease characterized by physiological intraocular hypertension that causes damage to the retinal ganglion cells (RGCs). In the past, RGC damage in POAG was suggested to have been attributed to RGC apoptosis. However, in the present study, we applied a model closer to human POAG through the use of a(More)
—Data deduplication is a lossless compression technology that replaces the redundant data chunks with pointers pointing to the already-stored ones. Due to this intrinsic data elimination feature, the deduplication commodity would de-linearize the data placement and force the data chunks that belong to the same data object to be divided into multiple(More)
PURPOSE Since the 78 kDa glucose-regulated protein (GRP78) is a key marker of endoplasmic reticulum (ER) stress, we investigated and analyzed GRP78 expression levels in the trabecular meshwork (TM) by eyes with primary open angle glaucoma (POAG) and normal eyes to understand the role of GRP78 in human TM cells apoptosis. METHODS Trabecular meshwork cells(More)
PURPOSE To investigate the efficacy, safety, and mechanisms of Sirolimus sustained delivery film on prevention of scar formation in a rabbit model of glaucoma filtration surgery. METHODS Sixty-four New Zealand white rabbits who underwent trabeculectomy in the right eye were randomly allocated to one of the four treatment regimens: Sirolimus sustained(More)
Our experimental study and analysis reveal that the bottlenecks of existing hardware transactional memory systems are largely rooted in the extra data movements in version management and in the inefficient scheduling of conflicting transactions in conflict management, particularly in the presence of high-contention and coarse-grained applications. In order(More)