Zhicai Shi

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Trytophan Hydroxylase Type I (TPH1), most abundantly expressed in the gastrointestinal tract, initiates the synthesis of serotonin by catalyzing hydroxylation of tryptophan in the presence of biopterin and oxygen. We have previously described three series of novel, periphery-specific TPH1 inhibitors that selectively deplete serotonin in the gastrointestinal(More)
At the forefront of new synthetic endeavors, such as drug discovery or natural product synthesis, large quantities of material are rarely available and timelines are tight. A miniaturized automation platform enabling high-throughput experimentation for synthetic route scouting to identify conditions for preparative reaction scale-up would be a(More)
—RFID is a key technology that can be used to create the pervasive society. The tag is an important part of the RFID system and most popular tags are some low-cost passive tags. These tags have limited computing and storing resources, and no more attentions are paid to their security and privacy. So the application of these tags is not secure. Lightweight(More)
—The data processed by intrusion detection systems usually is vague, uncertainty, imprecise and incomplete. Rough Set theory is one of the best methods to process this kind of data. But Rough Set theory can only process some discrete data. So the data with continuous numerical attributes must be discretized before they are used. Some current discretization(More)
The mammalian proline transporter (PROT) is a high affinity Na(+)/Cl(-)-dependent transporter expressed in specific regions of the brain. It is homologous to other neurotransmitter transporters such as glycine, norepinephrine, serotonin, and dopamine transporters. PROT is enriched in glutamatergic synaptic terminals and may play an important role in the(More)
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