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Short-Term Effects of the 2008 Cold Spell on Mortality in Three Subtropical Cities in Guangdong Province, China
- Huiyan Xie, Z. Yao, +10 authors Wenjun Ma
- Biology, Medicine
- Environmental health perspectives
- 31 October 2012
Background: Few studies have been conducted to investigate the impact of extreme cold events on mortality in subtropical regions. Objective: In the present study we aimed to investigate the effects… Expand
Protective effects of Ginkgo biloba extract (EGb761) and its constituents quercetin and ginkgolide B against beta-amyloid peptide-induced toxicity in SH-SY5Y cells.
- C. Shi, L. Zhao, +4 authors J. Xu
- Medicine, Chemistry
- Chemico-biological interactions
- 14 September 2009
Ginkgo biloba extract EGb761 has been shown to protect against beta-amyloid peptide (Abeta)-induced neurotoxicity but the specific mechanisms remain unclear. In the present study, effects of EGb761… Expand
Confirmation of susceptibility gene loci on chromosome 1 in northern China Han families with type 2 diabetes.
OBJECTIVE To confirm previous effort to identify type 2 diabetes susceptibility genes in a Northern Chinese population by conducting a new genome scan with both an increased number of type 2 diabetes… Expand
Distribution of nestin immunoreactivity in the normal adult human forebrain
The distribution of nestin immunoreactivity was studied in the whole normal adult human forebrains using new anti-human nestin mouse monoclonal and rabbit polyclonal antiserum. The nestin… Expand
Potential roles of Alzheimer precursor protein A4 and β‐amyloid in survival and function of aged spinal motor neurons after axonal injury
- Y. Xie, Z. Yao, H. Chai, Wai-Man Wong, W. Wu
- Biology, Medicine
- Journal of neuroscience research
- 15 August 2003
To study the potential role of Alzheimer precursor protein A4 (APP) and β‐amyloid (A/β) on aging motor neuron survival, expression of APP, A/β, and choline acetyltransferase (ChaT) were investigated… Expand
Effects of ageing and Alzheimer’s disease on mitochondrial function of human platelets
Mitochondrial dysfunction may play an important role in the pathogenesis of ageing and age-neurodegenerative diseases such as Alzheimer's disease (AD). Platelet mitochondrial membrane potential… Expand
Rapid pulmonary fibrosis induced by acute lung injury via a lipopolysaccharide three-hit regimen.
Based on the common characteristic of severe acute respiratory syndrome (SARS) and highly pathogenic avian influenza and the mechanism of inflammation and fibrosis, it is speculated that there should… Expand
Ginkgo biloba extract EGb761 protects against mitochondrial dysfunction in platelets and hippocampi in ovariectomized rats
Using ovariectomized middle-aged rats to mimic the post-menopausal pathophysiological changes in women, we have previously demonstrated that estrogen withdrawal and age-related decrease in the… Expand
Bilobalide Protects Mitochondrial Function in Ovariectomized Rats by Up-regulation of mRNA and Protein Expression of Cytochrome c Oxidase Subunit I
- C. Shi, J. Zou, Guoying Li, Z. Ge, Z. Yao, J. Xu
- Medicine, Biology
- Journal of Molecular Neuroscience
- 1 October 2011
Bilobalide (BB), a sesquiterpene trilactone from Ginkgo biloba has been proposed to have protective effects on mitochondrial function. Using ovariectomized rats to mimic the post-menopausal… Expand
4Aβ1-15-Derived Monoclonal Antibody Reduces More Aβ Burdens and Neuroinflammation than Homologous Vaccine in APP/PS1 Mice.
- Yuwei Zhang, Juntao Zou, Junhua Yang, Zhibin Yao
- Biology, Medicine
- Current Alzheimer research
- 1 May 2015
The common pathological hallmark of Alzheimer's disease (AD) is β-amyloid plaque deposition. The ideal therapy would reduce the Aβ burden with a low inflammatory immune response. Passive… Expand