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RP105 Protects Against Apoptosis in Ischemia/Reperfusion-Induced Myocardial Damage in Rats by Suppressing TLR4-Mediated Signaling Pathways
Background: Myocardial apoptosis is heavily implicated in the myocardial damage caused by ischemia-reperfusion (I/R). Toll-like receptor 4 (TLR4) is a potent inducer of these apoptotic cascades. InExpand
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The role of microRNAs in regulating myocardial ischemia reperfusion injury
Myocardial ischemia and reperfusion (I/R) injury is a pathological condition characterized by an initial restriction of blood supply to the heart followed by the subsequent restoration of perfusionExpand
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UCP2 protect the heart from myocardial ischemia/reperfusion injury via induction of mitochondrial autophagy
  • H. Wu, M. Ye, +7 authors J. Yang
  • Chemistry, Medicine
  • Journal of cellular biochemistry
  • 1 September 2019
Uncoupling protein 2 (UCP2), located in the mitochondrial inner membrane, is a predominant isoform of UCP that expressed in the heart and other tissues of human and rodent tissues. Nevertheless, itsExpand
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Arginine vasopressin antagonist tolvaptan in the treatment of heart failure: a meta-analysis of randomized controlled trials.
BACKGROUND Tolvaptan can promote water clearance without a deterioration of serum electrolytes in HF patients, but its efficacy and safety were unclear. We performed a meta-analysis of randomizedExpand
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Inhibition of microRNA‐327 ameliorates ischemia/reperfusion injury‐induced cardiomyocytes apoptosis through targeting apoptosis repressor with caspase recruitment domain
Apoptosis is the major cause of cardiomyocyte death in myocardial ischemia/reperfusion injury (MI/RI). Increasing evidence suggests that microRNAs (miRNAs) can contribute to the regulation ofExpand
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A Meta-Analysis of Randomized Clinical Trials Comparing Shorter (Less or Equal Than 6 Months) and Longer (More or Equal Than 12 Months) Dual Anti-Platelet Therapy Following Drug-Eluting Coronary
Context: The optimal duration of dual anti-platelet therapy (DAPT) after the implantation of drug-eluting coronary stents (DES) is still the subject of ongoing debate. This meta-analysis wasExpand
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Microribonucleic acids and vascular restenosis.
Microribonucleic acids (miRNAs) are small non-coding RNAs, which control diverse cellular functions by either promoting degradation or inhibiting target messenger RNA translation. An aberrantExpand
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MicroRNA-24 inhibits the oxidative stress induced by vascular injury by activating the Nrf2/Ho-1 signaling pathway.
BACKGROUND AND AIMS The process of endothelial repair in diabetic patients after stent implantation was significantly delayed compared with that in non-diabetic patients, and oxidative stress isExpand
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DPP-4 inhibitors: A potential promising therapeutic target in prevention of atherosclerosis.
Article history: Received 29 July 2015 Accepted 1 August 2015 Available online 5 August 2015 atherosclerosis. The underlying mechanisms of DPP-4 inhibitors protective roles in atherosclerosis areExpand
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