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RP105 Protects Against Apoptosis in Ischemia/Reperfusion-Induced Myocardial Damage in Rats by Suppressing TLR4-Mediated Signaling Pathways
Background: Myocardial apoptosis is heavily implicated in the myocardial damage caused by ischemia-reperfusion (I/R). Toll-like receptor 4 (TLR4) is a potent inducer of these apoptotic cascades. In… Expand
The role of microRNAs in regulating myocardial ischemia reperfusion injury
Myocardial ischemia and reperfusion (I/R) injury is a pathological condition characterized by an initial restriction of blood supply to the heart followed by the subsequent restoration of perfusion… Expand
UCP2 protect the heart from myocardial ischemia/reperfusion injury via induction of mitochondrial autophagy
Uncoupling protein 2 (UCP2), located in the mitochondrial inner membrane, is a predominant isoform of UCP that expressed in the heart and other tissues of human and rodent tissues. Nevertheless, its… Expand
Arginine vasopressin antagonist tolvaptan in the treatment of heart failure: a meta-analysis of randomized controlled trials.
- Chaojun Yang, J. Yang, J. Yang, Zhi-xing Fan
- International journal of clinical and…
- 15 December 2015
BACKGROUND Tolvaptan can promote water clearance without a deterioration of serum electrolytes in HF patients, but its efficacy and safety were unclear. We performed a meta-analysis of randomized… Expand
Inhibition of microRNA‐327 ameliorates ischemia/reperfusion injury‐induced cardiomyocytes apoptosis through targeting apoptosis repressor with caspase recruitment domain
- Q. Li, J. Yang, +7 authors Jingqing Yang
- Chemistry, Medicine
- Journal of cellular physiology
- 6 October 2019
Apoptosis is the major cause of cardiomyocyte death in myocardial ischemia/reperfusion injury (MI/RI). Increasing evidence suggests that microRNAs (miRNAs) can contribute to the regulation of… Expand
A Meta-Analysis of Randomized Clinical Trials Comparing Shorter (Less or Equal Than 6 Months) and Longer (More or Equal Than 12 Months) Dual Anti-Platelet Therapy Following Drug-Eluting Coronary…
Context: The optimal duration of dual anti-platelet therapy (DAPT) after the implantation of drug-eluting coronary stents (DES) is still the subject of ongoing debate. This meta-analysis was… Expand
Microribonucleic acids and vascular restenosis.
Microribonucleic acids (miRNAs) are small non-coding RNAs, which control diverse cellular functions by either promoting degradation or inhibiting target messenger RNA translation. An aberrant… Expand
Radioprotective 105kDa protein (RP105): Is a critical therapeutic target for alleviating ischemia reperfusion induced myocardial damage via TLR4 signaling pathway.
MicroRNA-24 inhibits the oxidative stress induced by vascular injury by activating the Nrf2/Ho-1 signaling pathway.
BACKGROUND AND AIMS The process of endothelial repair in diabetic patients after stent implantation was significantly delayed compared with that in non-diabetic patients, and oxidative stress is… Expand
DPP-4 inhibitors: A potential promising therapeutic target in prevention of atherosclerosis.
Article history: Received 29 July 2015 Accepted 1 August 2015 Available online 5 August 2015 atherosclerosis. The underlying mechanisms of DPP-4 inhibitors protective roles in atherosclerosis are… Expand