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HPLC analysis and pharmacokinetic study of quercitrin and isoquercitrin in rat plasma after administration of Hypericum japonicum thunb. extract.
TLDR
The validated HPLC method was successfully applied to pharmacokinetic studies of the two analytes in rat plasma after the oral administration of Hypericum japonicum thunb.
Determination and pharmacokinetic study of syringin and chlorogenic acid in rat plasma after administration of Aidi lyophilizer.
TLDR
A high-performance liquid chromatographic (HPLC) method was developed for the first time and successfully applied to the pharmacokinetic study of syringin and chlorogenic acid in rat plasma after intravenous administration of Aidi lyophilizer.
Developmental changes in the composition of five anthraquinones from Rheum palmatum as quantified by (1) H-NMR.
TLDR
This H-NMR method was applied successfully to explore the seasonal variations of the five major anthraquinones in R. palmatum, and provided quantitative results in reasonable agreement with those obtained by the HPLC-UV method.
[Simultaneous determination of matrine, oxysophocarpin and oxymatrine in rat plasma by HPLC-MS and its application in the pharmacokinetic study].
TLDR
The HPLC-MS method was shown to be effective, convenient, and suitable for simultaneous pharmacokinetic study of matrine, oxymatrine, and oxysophocarpine in rat.
Computational Insights into the Inhibition of Inosine 5′‐Monophosphate Dehydrogenase by Mycophenolic Acid Analogs: Three‐Dimensional Quantitative Structure–Activity Relationship and Molecular Docking
TLDR
Based on the CoMFA and CoMSIA contour maps and docking analyses, some key structural factors responsible for inhibitory activity were revealed and could be used for the rational design of potent inhibitors against IMPDH.
Three new phenolic glucosides from the roots of Rheum palmatum.
TLDR
A novel naphthalene glucoside, rheumone A, with an unprecedented skeleton containing a seven-membered lactone, and two new compounds, 1-O-phloroglucinyl-2- O-galloyl-6-O -cinnamoyl -β-D-glucoside and chrysophanol, together with three known compounds, showed cytotoxicity with IC(50) far beyond 50 μM.
Determination and Pharmacokinetic Study of Calycosin-7-O-β-d-glucoside in Rat Plasma After Intravenous Administration of Aidi Lyophilizer
Aidi injection is a clinical medicine used in China for the treatment of cancer. Calycosin-7-O-β-d-glucoside is the main effective components of the formulas. In this study, a high performance liquid
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