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BACKGROUND Chinese Uygur, Kazakh, Mongolian and Han populations represent >90% of the total population of Xinjiang Uygur Autonomous Region, and their genetic backgrounds, customs, culture, and food consumption are different. The effect of ethnic differences on cardiovascular disease risk factors (CRFs; hypertension, obesity, diabetes, dyslipidemia, smoking)(More)
BACKGROUND The prevalence of population-wide hypertension, obesity and dyslipidemia has not been well studied in the pasture area of Xinjiang. The present epidemiological study was performed to determine the prevalence of hypertension, obesity and dyslipidemia in minority populations from the pasture area of Xinjiang and to discuss the potential risk(More)
OBJECTIVE To study the lipids level in Kazakan individuals over 30-year-old in Fukang area of Xinjiang. METHODS Random cluster multistage sampling method were performed to select the subjects, and 991 individuals aged older than 30 from Fukang of Xinjiang were included. The plasma total cholesterol (TC), triglyceride (TG), high-density lipoprotein(More)
BACKGROUND G protein-coupled inward rectifier K+ channel 4 (GIRK4) gene expressions have been implicated in the development of obesity, a key feature of metabolic syndrome (MetS). We investigated whether sequence variants of GIRK4 may represent metabolic risk factors for the Uygur Chinese population. METHODS The entire GIRK4 gene, including all exons, the(More)
OBJECTIVE To investigate the association between the obstructive sleep apnea-hypopnea syndrome (OSAHS) in hypertension and insulin. METHODS A total of 521 patients were divided into 4 groups according to apnea-hypopnea index and OSAHS degrees. The control group (group I), mild OSAHS group (group II), moderate OSAHS group (group III) and severe OSAHS group(More)
OBJECTIVE To investigate the association of the 1891-1892del TC polymorphism of regulator of G-protein signalling 2 (RGS2) gene with hypertension in Xinjiang Kazakh population. METHODS The case-control study was performed in 444 cases and 489 controls. The genotypes of the individuals in the 1891-1892del TC locus were identified by TaqMan method. (More)
OBJECTIVE To investigate the relationship between human beta2-Adrenergic Receptor (ADRB2) gene C659G polymorphism and essential hypertension in Xinjiang Kazakans. METHODS Polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) methods were used to detect the C659G polymorphism of ADRB2 gene in 435 Kazakans including 273(More)
OBJECTIVE To investigate the effect of obesity, arousal, hypoxia and sympathetic activation on the circadian blood pressure of hypertensive patients with obstructive sleep apnea-hypopnea syndrome. METHODS Polysomnography (PSG) was performed in 436 hypertensive patients complaining of snoring, daytime sleepiness, lips cyanosis, hyperhemoglobinemia of(More)
OBJECTIVE To explore the relationship between six-transmembrane epithelial antigen of prostate 4 (STEAP4) genetic polymorphisms and insulin resistance (IR) in Uygur Chinese general population. METHODS In this cross-sectional study on the metabolic diseases (e.g. obesity) among Uygur Chinese in Hetian, Xinjiang, China,from January to February 2007, 2127(More)
OBJECTIVE To investigate the relationship between the genetic polymorphisms of the six transmembrane protein of prostate 2 gene (STAMP2) and essential hypertension in Xinjiang Uygur population. METHODS The sequences of STAMP2 gene functional region were sequenced in Xinjiang Uygur population with hypertension. The representative variations selected were(More)