Zhi-quan Wang

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BACKGROUND Recently, in a cross-sectional study of 201 children in Araihazar, Bangladesh, exposure to arsenic (As) in drinking water has been shown to lower the scores on tests that measure children's intellectual function before and after adjustment for sociodemographic features. OBJECTIVES We investigated the effects of As and fluoride exposure on(More)
Graves' disease is a common autoimmune disorder characterized by thyroid stimulating hormone receptor autoantibodies (TRAb) and hyperthyroidism. To investigate the genetic architecture of Graves' disease, we conducted a genome-wide association study in 1,536 individuals with Graves' disease (cases) and 1,516 controls. We further evaluated a group of(More)
Web video databases tend to contain immense copies with the explosive growth of online videos. How to detect video copies has become an essential problem for web video storage and indexing. This paper presents an efficient Hash scheme for video copy detection. By building trajectories of Harris points from frame to frame, behavior of interest points can be(More)
Doxorubicin (DOX) is a widely used antineoplastic agent for a variety of carcinomas. However, it is cardiotoxic and leads to cardiomyopathy. Previous studies have indicated that omega-3 polyunsaturated acids (ω-3 PUFAs) have therapeutic effects on dilated and diabetic cardiomyopathies. However, whether ω-3 PUFAs exert therapeutic effects on DOX-induced(More)
AIM To observe the effect of berberine on insulin secretion in rat pancreatic islets and to explore its possible molecular mechanism. METHODS Primary rat islets were isolated from male Sprague-Dawley rats by collagenase digestion and treated with different concentrations (1, 3, 10 and 30 micromol/L) of berberine or 1 micromol/L Glibenclamide (GB) for 24(More)
OBJECTIVE To study the relationship between 5,10-methylenetetrahydrofolate reductase(MTHFR) genetic polymorphism and arsenic metabolism and the role of folate in it. METHODS Forty-three individuals who were exposed to arsenic more than 0.05 mg/L in well water were chosen and the vein blood and morning urine was collected; The MTHFR C677 polymorphism was(More)
Hypoxia which is mainly mediated by hypoxia-inducible factor 1 (HIF-1), can greatly contribute to the occurrence of Alzheimer's disease (AD) by increasing beta-site APP cleaving enzyme (BACE1) gene expression, protein level and beta-secretase activity, resulting in a significant generation of amyloid-beta (Abeta). Salidroside has been reported to have great(More)
Parkinson's disease (PD) is a slowly progressive neurodegenerative disorder characterized clinically by bradykinesia, rigidity, tremor, gait dysfunction, and postural instability. Several genes have been identified for monogenic disorders that variably resemble Parkinson's disease. Here, we focus on PARK7, a gene relates to an autosomal recessive form of(More)
Type 2 diabetes (T2D) is associated with perturbed innate immunity. Macrophages, bridging innate immunity and metabolic disturbances, play important roles in controlling immune homeostasis. However, the effect of long-term diabetic milieu (DM) on the functions and phenotypes of macrophages is still not clear. In this study, we used resident peritoneal(More)
Abnormal activity detection for intelligent home care is presented in this paper. The activities have been catalogued into six possible classes, such as standing, sitting, squatting, walking, jogging, and falling down, among which falling down including on-marching falling down and in-place falling down is regarded as the abnormal activity. The output of(More)