• Publications
  • Influence
Anxiolytic-like effects of YL-IPA08, a potent ligand for the translocator protein (18 kDa) in animal models of post-traumatic stress disorder.
Recently, the translocator protein (18 kDa) (TSPO), previously called peripheral benzodiazepine receptor (PBR) and both the starting point and an important rate-limiting step in neurosteroidogenesis,Expand
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Enhanced MGMT expression contributes to temozolomide resistance in glioma stem-like cells
O6-methylguanine DNA methyltransferase (MGMT) can remove DNA alkylation adducts, thereby repairing damaged DNA and contributing to the drug resistance of gliomas to alkylating agents. In addition,Expand
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Repeated administration of AC-5216, a ligand for the 18kDa translocator protein, improves behavioral deficits in a mouse model of post-traumatic stress disorder
Post-traumatic stress disorder (PTSD) is a severely disabling anxiety disorder that may occur following exposure to a serious traumatic event. It is a psychiatric condition that can afflict anyoneExpand
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Involvement of allopregnanolone in the anti-PTSD-like effects of AC-5216
Cholesterol import into mitochondria through the translocator protein (18 KDa) (TSPO) is the starting point and an important rate-limiting step in neurosteroidogenesis. For this reason TSPO hasExpand
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Overexpression of IL-7 enhances cisplatin resistance in glioma
  • L. Cui, Jun Fu, +6 authors Z. Chen
  • Medicine, Biology
  • Cancer biology & therapy
  • 1 May 2012
Cisplatin is one of the most commonly used chemotherapeutic agents for glioma patients. In this study, array comparative genomic hybridization (aCGH) was used to identify genes associated withExpand
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The antidepressant-like activity of AC-5216, a ligand for 18KDa translocator protein (TSPO), in an animal model of diabetes mellitus
Diabetes mellitus is a chronic disease that is associated with depression. Also, depression is common in adults with type 2 diabetes mellitus (T2DM). Translocator protein (18kDa) (TSPO) andExpand
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Translocator protein mediates the anxiolytic and antidepressant effects of midazolam
The translocator protein (18 kDa) (TSPO) plays an important role in stress-related disorders, such as anxiety, depression and post-traumatic stress disorder (PTSD), caused by neurosteroids (e.g.Expand
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Puerarin ameliorated the behavioral deficits induced by chronic stress in rats
The present study aimed to investigate the mechanisms underlying the antidepressant-like effects of puerarin via the chronic unpredictable stress (CUS) procedure in rats. Similar to Sertraline (Ser),Expand
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Anxiolytic-like effects of paeoniflorin in an animal model of post traumatic stress disorder
Post-traumatic stress disorder (PTSD) is the serious psychiatric disorder. Paeoniflorin (PF) produces the antidepressant-like properties. However, few studies are concerned about its anti-PTSD-likeExpand
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Antidepressant-like effects of albiflorin extracted from Radix paeoniae Alba.
ETHNOPHARMACOLOGY RELEVANCE Albiflorin, a monoterpene glycoside, is a main component of Radix paeoniae Alba, which could be a Chinese herbal medicine used in the treatment of psychiatric disorders.Expand
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