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c-Maf Regulates IL-10 Expression during Th17 Polarization1
TLDR
Gene array analysis on Stat6 and T-bet double-deficient Th17 cells identified the Th2 transcription factor c-Maf to be synergistically up-regulated by IL-6 plus TGFβ and associated with Th17 IL-10 production, and it is suggested that TGF β may antagonize Th17 immunity by IL -10 production through c- Maf induction. Expand
Glucocorticoid Receptor and Sequential P53 Activation by Dexamethasone Mediates Apoptosis and Cell Cycle Arrest of Osteoblastic MC3T3-E1 Cells
TLDR
It is proved that dexamethasone can’t induce apoptosis and cell cycle arrest when p53 was inhibited by p53 RNA interference, and it is found that glucocorticoids play a pivotal role in the proliferation of osteoblasts, but the underlying mechanism has not been successfully elucidated. Expand
Increased synovial fluid visfatin is positively linked to cartilage degradation biomarkers in osteoarthritis
TLDR
Findings suggest that SF visfatin might involved in cartilage matrix degradation. Expand
Association of I27L polymorphism of hepatocyte nuclear factor-1 alpha gene with high-density lipoprotein cholesterol level.
TLDR
It is demonstrated that the HNF-1 alpha gene locus is associated with serum HDL-c level and suggested that the Ile27 allele is a risk marker for atherosclerosis. Expand
Overexpression of BMI-1 Promotes Cell Growth and Resistance to Cisplatin Treatment in Osteosarcoma
TLDR
These findings suggest a crucial role for BMI-1 in osteosarcoma pathogenesis and could be rescued by forced expression of BMI- 1 wobble mutant which is resistant to inhibition by the small interfering RNA (siRNA). Expand
Identification of Lympho-Epithelial Kazal-Type Inhibitor 2 in Human Skin as a Kallikrein-Related Peptidase 5-Specific Protease Inhibitor
TLDR
It is suggested that LEKTI-2 contributes to the regulation of the desquamation process in human skin by specifically inhibiting KLK5. Expand
Chemical chaperones reduce ER stress and adipose tissue inflammation in high fat diet-induced mouse model of obesity
TLDR
The present study revealed the possibility that inhibition of ER stress may be a novel drug target for metabolic abnormalities associated with obesity, and chemical chaperones suppress NF-κB activity in adipose tissue of obese mice in vivo. Expand
Molecular Identification and Expression Analysis of Filaggrin-2, a Member of the S100 Fused-Type Protein Family
TLDR
It is provided that like filaggrin, FLG2 is initially expressed by upper granular cells, proteolytically processed and deposited in the stratum granulosum and stratum corneum layers of normal epidermis, and may have overlapping and perhaps synergistic roles in the formation of the epidermal barrier. Expand
Synovial fluid level of adiponectin correlated with levels of aggrecan degradation markers in osteoarthritis
TLDR
Findings suggest that adiponectin might involve in the regulation of the degradation of cartilage matrix in OA. Expand
Leptin‐mediated cytoskeletal remodeling in chondrocytes occurs via the RhoA/ROCK pathway
TLDR
The results indicate that leptin activates the RhoA/ROCK/LIMK/cofilin pathway, which results in cytoskeletal reorganization in chondrocytes, which provides novel evidence supporting the possible involvement of leptin and the RHoA pathway in the pathogenesis of OA. Expand
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