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- Publications
- Influence
Genomic and molecular characterization of esophageal squamous cell carcinoma
- D. Lin, J. Hao, +22 authors H. Koeffler
- Biology, Medicine
- Nature Genetics
- 30 March 2014
Esophageal squamous cell carcinoma (ESCC) is prevalent worldwide and particularly common in certain regions of Asia. Here we report the whole-exome or targeted deep sequencing of 139 paired ESCC… Expand
Amplification of PRKCI, located in 3q26, is associated with lymph node metastasis in esophageal squamous cell carcinoma
DNA amplification is one of the mechanisms to activate genes that are implicated in neoplastic transformation and gain of chromosome band 3q26 is a common event in squamous cell carcinomas. The aim… Expand
Consistent and Differential Genetic Aberrations between Esophageal Dysplasia and Squamous Cell Carcinoma Detected By Array Comparative Genomic Hybridization
- Zhi-Zhou Shi, Li Shang, +9 authors M. Wang
- Biology, Medicine
- Clinical Cancer Research
- 5 September 2013
Purpose: Our aim was to identify frequent genomic aberrations in both esophageal squamous cell carcinoma (ESCC) and esophageal dysplasia and to discover important copy number-driving genes and… Expand
PLK1 Is Transcriptionally Activated by NF-κB during Cell Detachment and Enhances Anoikis Resistance through Inhibiting β-Catenin Degradation in Esophageal Squamous Cell Carcinoma
Purpose: To investigate the molecular mechanisms through which polo-like kinase-1 (PLK1) takes part in anoikis resistance of esophageal squamous cell carcinoma (ESCC) cells. Experimental Design: The… Expand
miR-145-5p Suppresses Tumor Cell Migration, Invasion and Epithelial to Mesenchymal Transition by Regulating the Sp1/NF-κB Signaling Pathway in Esophageal Squamous Cell Carcinoma
- Li-li Mei, Wen-Jun Wang, Y. Qiu, Xiu-Feng Xie, Jie Bai, Zhi-Zhou Shi
- Biology, Medicine
- International journal of molecular sciences
- 23 August 2017
MicroRNAs (miRNAs) play important roles in the progression of human cancer. Although previous reports have shown that miR-145-5p is down-regulated in esophageal squamous cell carcinoma (ESCC), the… Expand
Overexpression of PLK1 is associated with poor survival by inhibiting apoptosis via enhancement of survivin level in esophageal squamous cell carcinoma
- Yan-bin Feng, D. Lin, +11 authors M. Wang
- Biology, Medicine
- International journal of cancer
- 1 February 2009
PLK1 is essential for the maintenance of genomic stability during mitosis. In our study, we found that overexpression of PLK1 was an independent prognostic factor (RR = 4.253, p = 0.020) and… Expand
Identification of Genomic Alterations in Pancreatic Cancer Using Array-Based Comparative Genomic Hybridization
- J. Liang, Zhi-Zhou Shi, +9 authors M. Wang
- Biology, Medicine
- PloS one
- 11 December 2014
Background Genomic aberration is a common feature of human cancers and also is one of the basic mechanisms that lead to overexpression of oncogenes and underexpression of tumor suppressor genes. Our… Expand
Overexpression of DNAJB6 promotes colorectal cancer cell invasion through an IQGAP1/ERK‐dependent signaling pathway
- T. Zhang, Yan-Yi Jiang, +10 authors M. Wang
- Biology, Medicine
- Molecular carcinogenesis
- 1 October 2015
DNAJB6 is a member of the heat shock protein 40 (Hsp40) family. We here investigated the clinical correlation and biological role of DNAJB6 overexpression in colorectal cancer (CRC). The expression… Expand
Genomic profiling of rectal adenoma and carcinoma by array-based comparative genomic hybridization
- Zhi-Zhou Shi, Y. Zhang, +9 authors Y. Zhang
- Medicine, Biology
- BMC Medical Genomics
- 16 November 2012
BackgroundRectal cancer is one of the most common cancers in the world. Early detection and early therapy are important for the control of death caused by rectal cancer. The present study aims to… Expand
MCM7 amplification and overexpression promote cell proliferation, colony formation and migration in esophageal squamous cell carcinoma by activating the AKT1/mTOR signaling pathway.
- Y. Qiu, Wen-Jun Wang, B. Zhang, Li-li Mei, Zhi-Zhou Shi
- Biology, Medicine
- Oncology reports
- 1 June 2017
The roles and mechanisms of mini-chromosome maintenance complex component 7 (MCM7) amplification and overexpression in esophageal carcinogenesis were investigated. By analyzing the TCGA datasets, we… Expand