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Genomic and molecular characterization of esophageal squamous cell carcinoma
TLDR
The whole-exome or targeted deep sequencing of 139 paired ESCC cases and analysis of somatic copy number variations (SCNV) of over 180 ESCCs provide an important molecular foundation for understanding esophageal tumors and developing therapeutic targets.
Amplification of PRKCI, located in 3q26, is associated with lymph node metastasis in esophageal squamous cell carcinoma
TLDR
The results indicate that PRKCI is an attractive target in the 3q26 amplicon and that it may serve as a molecular marker for metastasis and occult advanced tumor stages in ESCC.
Consistent and Differential Genetic Aberrations between Esophageal Dysplasia and Squamous Cell Carcinoma Detected By Array Comparative Genomic Hybridization
TLDR
Copy number aberrations in both esophageal dysplasia and ESCC may be useful as potential biomarkers for early detection and ANO1 may be a candidate target gene in esophagal tumorigenesis.
PLK1 Is Transcriptionally Activated by NF-κB during Cell Detachment and Enhances Anoikis Resistance through Inhibiting β-Catenin Degradation in Esophageal Squamous Cell Carcinoma
TLDR
Findings suggest that upregulation of PLK1 triggered by cell detachment is regulated by RelA at the transcriptional level, which reveals critical mechanisms involved in the role of RelA/PLK1/β-catenin in anoikis resistance of ESCC cells.
miR-145-5p Suppresses Tumor Cell Migration, Invasion and Epithelial to Mesenchymal Transition by Regulating the Sp1/NF-κB Signaling Pathway in Esophageal Squamous Cell Carcinoma
TLDR
The results suggested that miR-145-5p plays tumor-suppressive roles by inhibiting esophageal cancer cell migration, invasion and EMT through regulating the Sp1/NF-κB signaling pathway.
Overexpression of PLK1 is associated with poor survival by inhibiting apoptosis via enhancement of survivin level in esophageal squamous cell carcinoma
TLDR
It is found that overexpression of PLK1 was an independent prognostic factor and significantly correlated with survivin, an antiapoptotic protein, in esophageal squamous cell carcinoma (ESCC), and data suggest thatPLK1 might be a useful prognostic marker and a potential therapeutic target for ESCC.
MicroRNAs in esophageal squamous cell carcinoma: Potential biomarkers and therapeutic targets.
TLDR
A review of the diagnosis and prognosis associated oncogenic microRNAs and target gene pairs in esophageal cancer highlights the opportunities and challenges for micro RNAs in the molecular diagnosis and target therapy of ESCC.
Overexpression of DNAJB6 promotes colorectal cancer cell invasion through an IQGAP1/ERK‐dependent signaling pathway
TLDR
The data suggest that DNAJB6 plays an important oncogenic role in CRC cell invasion by up‐regulating IQGAP1 and activating the ERK signaling pathway and thatDNAJB6 may be used as a prognostic marker for CRC.
Genomic profiling of rectal adenoma and carcinoma by array-based comparative genomic hybridization
TLDR
The authors' data may help to identify the driving genes involved in the adenoma-carcinoma progression and Protein and mRNA expression of GPNMB was significantly higher in cancer tissues than rectal adenomas tissues.
Dihydroartemisinin Inhibits the Proliferation, Colony Formation and Induces Ferroptosis of Lung Cancer Cells by Inhibiting PRIM2/SLC7A11 Axis
TLDR
DHA inhibited the proliferation, colony formation and enhanced cell death and induced ferroptosis of lung cancer cells by inactivating PRIM2/SLC7A11 axis, and might developed to be a novel therapeutic method in lung cancer therapy.
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