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Type I insulin-like growth factor receptor (IGF-IR), which is frequently overexpressed in a variety of human cancers including lung cancer, mediates cancer cell proliferation and tumor growth. In this study, we used a human U6 promoter-driven DNA-template approach to induce hairpin RNA (hpRNA)-triggered RNAi to silence IGF-IR gene expression in the human(More)
Polymer-derived carbon aerogels can be obtained by direct polymerization of monomers under hypersaline conditions using inorganic salts. This allows for significantly increased mechanical robustness and avoiding special drying processes. This concept was realized by conducting the polymerization of phenol-formaldehyde (PF) in the presence of ZnCl2 salt.(More)
Pinus koraiensis in broad-leaved Korean pine forests of Changbai Mountain at different successional stages (secondary poplar-birch forest, secondary coniferous and broad-leaved forest and the primitive Korean pine forest) were selected in this paper as the research objects. In this research, the annual growth of net primary productivity (NPP) (1921-2006) of(More)
OBJECTIVE To investigate the biological behaviors and chemosensitivity of non-small cell lung cancer (NSCLC) cell line A549 after IGF-IR gene silencing by RNA interference (RNAi) in vitro. METHODS Two plasmids siRNA 1 and 2 expressing IGF-IR siRNA with human U6 promoter were constructed,and an unrelated siRNA was used as negative control. NSCLC A549 cells(More)
NMDARs and ASIC1a both exist in central synapses and mediate important physiological and pathological conditions, but the functional relationship between them is unclear. Here we report several novel findings that may shed light on the functional relationship between these two ion channels in the excitatory postsynaptic membrane of mouse hippocampus.(More)
This study optimized the nitrite degradation conditions and explored the characteristics of nitrite degradation with redox mediators and nitrite denitrifying bacteria. The results suggested that the optimal condition of nitrite denitrification was 35 degrees C, pH = 8.0, sodium succinate as the carbon source, the C/N rate of 4 and the initial nitrite(More)
OBJECTIVE To study the effects of RNA interference (RNAi)-mediated insulin-like growth factor I receptor (IGF-IR) gene silencing on human lung cancer cells. METHODS Plasmids expressing IGF-IR shRNA1 and IGF-IR shRNA2 were constructed. Human non-small cell lung cancer cells of the line A549 were cultured and transfected with sequence-specific shRNA. RT-PCR(More)
A handful of abnormal data exist in harmonic current monitoring data, affecting the accuracy of the harmonic source localization and harmonic contribution assessment. In this paper, the distribution model of harmonic current monitoring data is established using three-parameter Weibull distribution according to the statistical characteristics of the harmonic(More)