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None of the integrins known to be present on the mouse egg or to be ADAM receptors are essential for sperm-egg binding and fusion.

• Zhi-Yong He, Cord Brakebusch, Reinhard Fässler, Jordan A. Kreidberg, Paul Primakoff, Diana Gold Myles
• Developmental biology
• 2003

Antibody inhibition and alpha6beta1 ligand binding experiments indicate that the egg integrin alpha6beta1 functions as a receptor for sperm during gamete fusion; yet, eggs null for the alpha6… (More)

Oocyte CD9 is enriched on the microvillar membrane and required for normal microvillar shape and distribution.

• Kathryn E Runge, James E Evans, +5 authors Diana Gold Myles
• Developmental biology
• 2007

Microvilli are found on the surface of many cell types, including the mammalian oocyte, where they are thought to act in initial contact of sperm and oocyte plasma membranes. CD9 is currently the… (More)

Loss of surface EWI-2 on CD9 null oocytes.

• Zhi-Yong He, Surabhi Gupta, Diana Gold Myles, Paul Primakoff
• Molecular reproduction and development
• 2009

CD9, a member of the tetraspanin family, associates with a variety of other proteins to form the tetraspanin web. CD9 forms direct and relatively stable associations with the immunoglobulin… (More)

A Structure-function Analysis of Human GDNF.

• Z. L. Chen, Zhi-Yong He, Cheng He, Chang-lin Lu, Xiang-fu Wu
• Sheng wu hua xue yu sheng wu wu li xue bao Acta…
• 2000

The glial cell line-derived neurotrophic factor(GDNF) plays a very important role in the regeneration of the nervous system. Based on the results of the X-ray structure analysis of rat GDNF, human… (More)

Reduced Circulating Levels of miR-433 and miR-133b Are Potential Biomarkers for Parkinson’s Disease

• Xiong Zhang, Rui Yang, +5 authors Jian-hong Zhu
• Front. Cell. Neurosci.
• 2017

Aberrant expression of microRNA (miRNA) in tissues may lead to altered level in circulation. Considerable evidence has suggested that miRNA deregulation is involved in the pathogenesis of Parkinson's… (More)

A Candidate Oral Vaccine to Helicobacter pylori Fusion Protein of HspA and CtxB.

• Ming-feng Li, Zhi-Yong He, +4 authors Xiang-fu Wu
• Sheng wu hua xue yu sheng wu wu li xue bao Acta…
• 2001

Heat-shock protein A subunit(HspA), an effective immunogen may stimulate the immunoresponse in human body against challenge of H.pylori. The B subunit of cholera toxin (CtxB) has been proved to be a… (More)

High Expression of Human Persephin in Insect Cells.

• Z. L. Chen, Zhi-Yong He, Cheng He, Chang-lin Lu, Xiang-fu Wu
• Sheng wu hua xue yu sheng wu wu li xue bao Acta…
• 2000

The human persephin (PSP) was expressed in Tn-5B1-4 insect cells using the Bac to Bac baculovirus expression system. The expressed product amounted for 20% of total cellular soluble proteins. The… (More)

Cloning and Expression of Tetanus Toxin Fragment C in E.coli.

• Huanlang He, Zhi-Yong He, +4 authors Xiang-fu Wu
• Sheng wu hua xue yu sheng wu wu li xue bao Acta…
• 2000

The fragment C of tetanus toxin was amplified from Clostridium tetani DNA by PCR. This fragment was cloned into expression vector pET-28a(+),under the control of the T7 promoter. Expression of this… (More)

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