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Estrogen promotes breast cancer metastasis. However, the detailed mechanism remains largely unknown. The actin binding protein ezrin is a key component in tumor metastasis and its over-expression is positively correlated to the poor outcome of breast cancer. In this study, we investigate the effects of 17β-estradiol (E2) on the activation of ezrin and its(More)
Because of the unconstrained environment of scene text, traditional Optical Character Recognition (OCR) engines fail to achieve satisfactory results. In this paper, we propose a new technique which employs first order Histogram of Oriented Gradient (HOG) through a spatial pyramid. The spatial pyramid can encode the relative spatial layout of the character(More)
BACKGROUND Ribosomal protein S6 (rpS6), a component of the 40S ribosomal subunit, is involved in multiple cellular bioactivities. However, its clinicopathological significance in non-small cell lung cancer (NSCLC) is poorly understood. METHODS Expressions of total rpS6 (t-rpS6) and phosphorylated rpS6 (Ser235/236, p-rpS6) were detected(More)
The mechanisms of progesterone on endothelial cell motility are poorly investigated. Previously we showed that progesterone stimulated endothelial cell migration via the activation of actin-binding protein moesin, leading to actin cytoskeleton remodelling and the formation of cell membrane structures required for cell movement. In this study, we(More)
The aim of this study was to evaluate the clinical applicability of rectilinear distraction osteogenesis for repairing alveolar cleft models. Alveolar process distraction surgery to produce bilateral clefts was performed on six adult cats. In our study, the left side with the distraction device was the experimental side, and the other side without a(More)
BACKGROUND Although patients with kidney disease have potential to benefit from revascularization, they are also at higher risk of complications, which may affect quality of life. METHODS AND RESULTS We studied a cohort of 8198 adults who underwent coronary angiography in Alberta, between 2004 and 2008, and completed health-related quality-of-life(More)
ORM1 is a plasma drug binding protein. Its polymorphism rs17650 (*S>*F) has been reported to be an important factor affecting the binding ability and effect of antiretroviral protease inhibitors. The aim of this study was to determine whether the ORM1 rs17650 polymorphism also influences warfarin therapy. A total of 191 Chinese patients with steady-dose(More)
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