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Wnk1 kinase deficiency lowers blood pressure in mice: A gene-trap screen to identify potential targets for therapeutic intervention
It is demonstrated that Wnk1 is a regulator of blood pressure critical for development and illustrate the utility of a functional screen driven by a sequence-based mutagenesis approach. Expand
Overexpression of Cdc25B, an androgen receptor coactivator, in prostate cancer
It is demonstrated that Cdc25B acts as a coactivator for AR in a hormone-dependent manner in the prostate cancer cell line, LNCaP, and directly interacts with AR as evidenced in GST-pull down and mammalian two-hybrid assays. Expand
Deregulated CDC25A expression promotes mammary tumorigenesis with genomic instability.
Deregulated control of cellular CDC25A levels leads to in vivo genomic instability, which cooperates with the neu-ras oncogenic pathway in mammary tumorigenesis, according to array-based comparative genomic hybridization and karyotyping. Expand
Induction of mammary gland hyperplasia in transgenic mice over-expressing human Cdc25B
It is reported that the over-expression of Cdc25B enhances the proliferation of mammary epithelial cells resulting in the formation of precocious alveolar hyperplasia, indicating that the deregulated expression of CDC25B generates mammary gland hyperplasticity. Expand
Inducible expression of FGF-3 in mouse mammary gland
It is shown that the persistence of mitogenic signal elicited by FGF-3 is crucial for the initiation, progression, and maintenance of the hyperplastic characteristic of the mammary epithelium. Expand
Cdc25B Functions as a Novel Coactivator for the Steroid Receptors
  • Zhi-Qing Ma, Zheng Liu, E. Ngan, Sophia Y. Tsai
  • Biology, Medicine
  • Molecular and Cellular Biology
  • 1 December 2001
A novel function of Cdc25B is uncovered that serves as a steroid receptor coactivator in addition to its role as a regulator for cell cycle progression, which might likely contribute to its oncogenic action in breast cancer. Expand
Design, Synthesis and Fungicidal Activities of Some Novel Pyrazole Derivatives
In order to discover new compounds with good fungicidal activities, 32 pyrazole derivatives were designed and synthesized and exhibited considerable antifungal activities, especially compound 26 containing a p-trifluoromethyl- phenyl moiety showed the highest activity. Expand
New Cytotoxic Secondary Metabolites from Marine Bryozoan Cryptosula pallasiana
A new sterol, (23R)-methoxycholest-5,24-dien-3β-ol (1), two new ceramides, (2S,3R,4E,8E)-2-(tetradecanoylamino)-4,8-octadecadien-l,3-diol (6) andExpand
Synthesis and Antifungal Activity of Carabrone Derivatives
Nine derivatives 6-14 of carabrone were synthesized and tested in vitro against Colletotrichum lagenarium using the spore germination method, and structure-activity relationships (SAR) demonstrated that the γ-lactone was necessary for the antifungal activity of 1, and the substituents on the C-4 position of 1 could significantly affect the antIFungalactivity. Expand
Fumigant activity of eleven essential oil compounds and their selected binary mixtures against Culex pipiens pallens (Diptera: Culicidae)
Results revealed that carvacrol, thymol, and their binary mixture have potential for the development of natural fumigants for adult mosquito control. Expand