Zhi-Qiang Wang

Rui-Hua Xu6
Miao-Zhen Qiu6
Yu-Hong Li6
Dong-Sheng Zhang6
6Rui-Hua Xu
6Miao-Zhen Qiu
6Yu-Hong Li
6Dong-Sheng Zhang
6Feng-Hua Wang
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In this paper, a local minimax-Newton method is developed to solve for multiple saddle points. The local minimax method [15] is used to locate an initial guess and a version of the generalized Newton method is used to speed up convergence. When a problem possesses a symmetry, the local minimax method is invariant to the symmetry. Thus the symmetry can be(More)
BACKGROUND Hemorrhagic fever with renal syndrome (HFRS) is a rodent-borne disease caused by Hantaviruses. It is endemic in all 31 provinces, autonomous regions, and metropolitan areas in mainland China where human cases account for 90% of the total global cases. Shandong Province is among the most serious endemic areas. HFRS cases in Shandong Province were(More)
The deregulation of paxillin (PXN) has been involved in the progression and metastasis of different malignancies including colorectal cancer (CRC). miR-137 is frequently suppressed in CRC. PXN is predicted to be a direct target of miR-137 in CRC cells. On this basis, we hypothesized that overexpression of PXN induced by suppression of miR-137 may promote(More)
Primary small cell carcinoma of the esophagus (SCCE) is a highly aggressive disease characterized by early dissemination and poor prognosis. Because of the rarity of this disease, few previous studies have investigated the biomarkers associated with its prognosis. Leucine-rich repeat-containing G-protein coupled receptor 5 (Lgr5) is a stem cell marker and a(More)
  • Carolina Muscoli, Vincenzo Mollace, James Wheatley, Emanuela Masini, Michael Ndengele, Zhi-Qiang Wang +1 other
  • 2004
N-methyl-D-aspartate (NMDA) receptors serve prominent roles in vast physio-pathological conditions including hyperalgesia (defined as augmented pain intensity in response to painful stimuli) associated with central sensitization. Using M40403 a synthetic low molecular weight superoxide dismutase mimetic that removes superoxide we show for the first time(More)
Previously, we have identified the polypeptide N-acetylgalactosaminyltransferase 3 (GALNT3) gene as notably hypomethylated in low-malignant potential (LMP) and high-grade (HG) serous epithelial ovarian tumors, compared to normal ovarian tissues. Here we show that GALNT3 is strongly overexpressed in HG serous EOC tumors as compared to normal ovarian tissue.(More)
The two neural melanocortin receptors (MCRs), melanocortin-3 and -4 receptors (MC3R and MC4R), are G protein-coupled receptors expressed primarily in the brain that regulate different aspects of energy homeostasis. The MCRs are unique in having endogenous antagonists, agouti and agouti-related protein (AgRP). These antagonists were later shown to be inverse(More)
  • Zhi-Qiang Wang, Mamadou Keita, Magdalena Bachvarova, Stephane Gobeil, Chantale Morin, Marie Plante +5 others
  • 2013
Previously, we have identified the RUNX2 gene as hypomethylated and overexpressed in post-chemotherapy (CT) primary cultures derived from serous epithelial ovarian cancer (EOC) patients, when compared to primary cultures derived from matched primary (prior to CT) tumors. However, we found no differences in the RUNX2 methylation in primary EOC tumors and EOC(More)