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Disruption of the MIG1 gene enhances lipid biosynthesis in the oleaginous yeast Yarrowia lipolytica ACA-DC 50109.
TLDR
Biosynthesis of C18:1 fatty acid in the disruptant M25 was greatly enhanced compared to that in the parent yeast, and transcript level of the MFE1 gene, one of the genes relevant to fatty acid degradation was reduced in the disrupting molecule.
Chemical synthesis of proteins using peptide hydrazides as thioester surrogates
TLDR
The utility of the protocol is shown for the total synthesis of 140-aa-long α-synuclein, a protein that has an important role in the development of Parkinson's disease.
Yeast killer toxins, molecular mechanisms of their action and their applications
TLDR
Killer toxins secreted by some yeast strains are the proteins that kill sensitive cells of the same or related yeast genera and many new targets including different components of cell wall, plasma membrane, tRNA, DNA and others in the sensitive cells for the killer toxin action have been identified so that the new molecular mechanisms of action have be elucidated.
Microbial biosynthesis and secretion of l-malic acid and its applications
TLDR
To enhance l- malate biosynthesis and secretion by microbial cells, it is very important to study the mechanisms of l-malic acid biosynthetic and secretion at enzymatic and molecular levels.
An efficient one-pot four-segment condensation method for protein chemical synthesis.
TLDR
A new one-pot multisegment peptide ligation method that can be used to condense up to four segments with operational simplicity and high efficiency is reported.
High level lipid production by a novel inulinase-producing yeast Pichia guilliermondii Pcla22.
TLDR
It was found that the yeast strain Pcla22 could produce higher amount of oil and more lipid bodies in its cells than any other yeast strains tested in this study.
Citric acid production from extract of Jerusalem artichoke tubers by the genetically engineered yeast Yarrowia lipolytica strain 30 and purification of citric acid
TLDR
Results showed that natural components of extract of Jerusalem artichoke tubers without addition of any other components were suitable for citric acid production by the yeast strain Yarrowia lipolytica strain 30.
Tumor-Associated Macrophages are Correlated with Tamoxifen Resistance in the Postmenopausal Breast Cancer Patients
TLDR
Examining the expression of epidermal growth factor receptor (EGFR) and CD163+ macrophages in 100 breast cancer tissues found positive correlations with tumor size, lymph node metastasis and obesity, and TAMs may be associated with tamoxifen resistance.
Flow injection on-line solid phase extraction coupled with inductively coupled plasma mass spectrometry for determination of (Ultra)trace rare earth elements in environmental materials using maleic
TLDR
The developed method was successfully applied to the determination of (ultra)trace rare earth elements (REEs) in sediment, soil, and seawater samples.
A genome-wide scan of selective sweeps in two broiler chicken lines divergently selected for abdominal fat content
TLDR
A genome-wide map of selection signatures in the chicken genome is provided to make a contribution to the better understanding of the mechanisms of selection for AF content in chickens.
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