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The genetics of complex disease produce alterations in the molecular interactions of cellular pathways whose collective effect may become clear through the organized structure of molecular networks. To characterize molecular systems associated with late-onset Alzheimer's disease (LOAD), we constructed gene-regulatory networks in 1,647 postmortem brain(More)
OBJECTIVE Genetic approaches have identified numerous loci associated with coronary heart disease (CHD). The molecular mechanisms underlying CHD gene-disease associations, however, remain unclear. We hypothesized that genetic variants with both strong and subtle effects drive gene subnetworks that in turn affect CHD. APPROACH AND RESULTS We surveyed(More)
The nucleolar protein PinX1 has been proposed to be a putative tumor suppressor due to its binding to and inhibition of the catalytic activity of telomerase, an enzyme that is highly expressed in most human cancers in which it counteracts telomere shortening-induced senescence to confer cancer cell immortalization. However, the role of PinX1 in telomere(More)
Inhibition of DNA Methyltransferase Activates Tumor Necrosis Factor –Induced Monocytic Differentiation in Acute Myeloid Leukemia Cells. Anna Laurenzana, Luca A. Petruccelli, Filippa Pettersson, Maria Eugenia Figueroa, Ari Melnick, Albert S. Baldwin, Francesco Paoletti, and Wilson H. Miller, Jr.(More)
The incidence of unfused ossicles in the lumbar spine, in radiographic studies, is 0.7-1.5%. With a sledge cryomicrotome, we sectioned 273 lumbar facet joints in 38 adult cadavers and correlated the anatomic appearance of the joints with CT and magnetic resonance (MR) images. Ossicles were present in 13% of the cadavers and 2.6% of the facet joints and were(More)
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