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—The emerging high efficiency video coding standard (HEVC) adopts the quadtree-structured coding unit (CU). Each CU allows recur-sive splitting into four equal sub-CUs. At each depth level (CU size), the test model of HEVC (HM) performs motion estimation (ME) with different sizes including , , , and. ME process in HM is performed using all the possible(More)
With the recent explosion of scientific data of unprecedented size and complexity, feature ranking and screening are playing an increasingly important role in many scientific studies. In this article, we propose a novel feature screening procedure under a unified model framework, which covers a wide variety of commonly used parametric and semiparametric(More)
Hepatitis C virus (HCV) infection frequently persists despite substantial virus-specific cellular immune responses. To determine if immunologically driven sequence variation occurs with HCV persistence, we coordinately analyzed sequence evolution and CD8+ T cell responses to epitopes covering the entire HCV polyprotein in subjects who were followed(More)
BACKGROUND Phytocyanins (PCs) are plant-specific blue copper proteins involved in electron transport, and a large number of known PCs are considered to be chimeric arabinogalactan proteins (AGPs). To date there has not been a genome-wide overview of the OsPC gene family. Therefore, as the first step and a useful strategy to elucidate the functions of OsPCs,(More)
In this paper, a probabilistic fuzzy logic system (PFLS) is proposed for the modeling and control problems. Similar to the ordinary fuzzy logic system (FLS), the PFLS consists of the fuzzification, inference engine and defuzzification operation to process the fuzzy information. Different to the FLS, it uses the probabilistic modeling method to improve the(More)
It is increasingly common for enterprises and other organizations to outsource network processing to the cloud. For example, enterprises may outsource fire-walling, caching, and deep packet inspection, just as they outsource compute and storage. However, this poses a threat to enterprise confidentiality because the cloud provider gains access to the(More)
CONTEXT Genetic alterations in receptor tyrosine kinases (RTKs) and phosphatidylinositol 3-kinase (PI3K)/Akt and MAPK pathways have not been fully defined in anaplastic and follicular thyroid cancers [anaplastic thyroid cancer (ATC), follicular thyroid cancer (FTC)]. OBJECTIVE The objective of the study was to explore a wide-range genetic basis for the(More)
Graves' disease (GD) is one of the most common human autoimmune diseases, and recent data estimated a prevalence of clinical hyperthyroidism of 0.25-1.09% in the population. Several reports have linked GD to the region 5q12-q33; and a locus between markers D5s436 and D5s434 was specifically linked to GD susceptibility in the Chinese population. In the(More)
In the human autoimmune blistering disease pemphigus vulgaris (PV) pathogenic antibodies bind the desmosomal cadherin desmoglein-3 (dsg3), causing epidermal cell-cell detachment (acantholysis). Pathogenic PV dsg3 autoantibodies were used to initiate desmosome signaling in human keratinocyte cell cultures. Heat shock protein 27 (HSP27) and p38MAPK were(More)
Mitochondrial DNA (mtDNA) contains unmethylated CpG motifs that exhibit immune stimulatory capacities. The aim of this study was to investigate whether mtDNA activates the Toll-like receptor 9 (TLR9)/nuclear factor-κB (NF-κB) pathway, thereby contributing to post-traumatic systemic inflammatory response syndrome (SIRS) and lung injury in rats. The effects(More)