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Triptolide: progress on research in pharmacodynamics and toxicology.
TLDR
Triptolide, a biologically active natural product extracted from the root of Tripterygium wilfordii, has shown promising pharmacological effects, particularly as an anti-tumor agent, in traditional Chinese medicine and in anti-cancer research. Expand
Prevention of free fatty acid–induced hepatic lipotoxicity by 18β‐glycyrrhetinic acid through lysosomal and mitochondrial pathways
TLDR
GA significantly reduced FFA/HFD‐induced hepatic lipotoxicity by stabilizing the integrity of lysosomes and mitochondria and inhibiting cathepsin B expression and enzyme activity, and reduce FFA‐induced oxidative stress. Expand
Telmisartan prevention of LPS-induced microglia activation involves M2 microglia polarization via CaMKKβ-dependent AMPK activation
TLDR
The results indicate that telmisartan can be considered as a novel AMPK activator, suppressing microglia activation by promoting M2 polarization and reducing M1 polarization in LPS-stimulated BV2 and primarymicroglia cells. Expand
Triptolide induces adverse effect on reproductive parameters of female Sprague-Dawley rats
TLDR
Reduced levels of E2 and P may affect follicular development, estrous cycle, and expression of ERα in ovaries and the uterus, and the decrease in steroids elicited feedback on FSH and LH. Expand
Involvement of mitochondrial pathway in triptolide-induced cytotoxicity in human normal liver L-02 cells.
TLDR
Results indicate that triptolide induced cytotoxicity in L-02 cells by apoptosis, which is mediated through mitochondrial pathway. Expand
The role of long noncoding RNA H19 in gender disparity of cholestatic liver injury in multidrug resistance 2 gene knockout mice
TLDR
Knocking down H19 not only significantly reduced taurocholate/estrogen‐induced expression of fibrotic genes and sphingosine 1‐phosphate receptor 2 in cholangiocytes but also markedly reduced cholestatic injury in female Mdr2–/– mice. Expand
A Panel of Serum MicroRNAs as Specific Biomarkers for Diagnosis of Compound- and Herb-Induced Liver Injury in Rats
TLDR
It is demonstrated that this panel of serum miRNAs provides potential biomarkers for diagnosis of DILI with high sensitivity and specificity. Expand
Glycyrrhizin accelerates the metabolism of triptolide through induction of CYP3A in rats.
TLDR
Pretreatment with GL significantly accelerates the metabolic elimination of TP from the body mainly through induction of hepatic CYP3A activity, which may help explain why toxicity of TP may be attenuated with concomitant use of GL. Expand
Effects of triptolide from Tripterygium wilfordii on ERalpha and p53 expression in two human breast cancer cell lines.
TLDR
The results showed that triptolide is much more sensitive to ERalpha-positive MCF-7 cells than to ER alpha-negative MDA-MB-231 cells, and the sensitivity is significantly associated with the ERalpha and p53 status. Expand
Inhibition of mitochondrial respiratory chain is involved in triptolide-induced liver injury.
TLDR
Results indicate that the secondary β-oxidation impairment caused by inhibition of mitochondrial respiratory chain is involved in triptolide-induced liver injury, which featured by microvesicular steatosis, hyperlactacidemia and enhanced oxidant stress, although other mechanisms of triptoide- induced liver injury may also exist. Expand
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