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Endogenous miRNA sponge lincRNA-RoR regulates Oct4, Nanog, and Sox2 in human embryonic stem cell self-renewal.
The embryonic stem cell (ESC) transcriptional and epigenetic networks are controlled by a multilayer regulatory circuitry, including core transcription factors (TFs), posttranscriptional modifierExpand
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MicroRNA-181 Regulates CARM1 and Histone Aginine Methylation to Promote Differentiation of Human Embryonic Stem Cells
As a novel epigenetic mechanism, histone H3 methylation at R17 and R26, which is mainly catalyzed by coactivator-associated protein arginine methyltransferase 1 (CARM1), has been reported to modulateExpand
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LncRNA MALAT1 regulates oxLDL-induced CD36 expression via activating β-catenin.
The expression of scavenger receptors in macrophages regulating lipid uptake plays an important role in foam cell formation and the subsequent atherosclerotic plaque formation. Long non-coding RNAExpand
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Potentiation of the anticancer effect of doxorubicinin drug-resistant gastric cancer cells by tanshinone IIA.
  • Zhenyu Xu, Lu Chen, +11 authors J. Shen
  • Chemistry, Medicine
  • Phytomedicine : international journal of…
  • 1 December 2018
BACKGROUND Gastric cancer is the fifth commonest cancer and the third cause of cancer-related deaths all over the world. The effectiveness of chemotherapy is still limited by drug resistance inExpand
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Protective Role of mPGES-1 (Microsomal Prostaglandin E Synthase-1)–Derived PGE2 (Prostaglandin E2) and the Endothelial EP4 (Prostaglandin E Receptor) in Vascular Responses to Injury
Objective— Deletion of mPGES-1 (microsomal prostaglandin E synthase-1)—an anti-inflammatory target alternative to COX (cyclooxygenase)-2—attenuates injury-induced neointima formation in mice. This isExpand
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Long non-coding RNA GAS5 controls human embryonic stem cell self-renewal by maintaining NODAL signalling
Long non-coding RNAs (lncRNAs) are known players in the regulatory circuitry of the self-renewal in human embryonic stem cells (hESCs). However, most hESC-specific lncRNAs remain uncharacterized.Expand
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Comprehensive molecular profiling of the B7 family of immune-regulatory ligands in breast cancer
ABSTRACT The B7 gene family has crucial roles in the regulation of adaptive cellular immunity. In cancer, deregulation of co-inhibitory B7 molecules is associated with reduced antitumor immunity andExpand
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Macrophage polarization and function: new prospects for fibrotic disease
Fibrosis is commonly regarded as a pathological and dynamic process with the hallmarks of chronic inflammation and wound healing. Emerging evidence indicates that heterogeneous monocyte–macrophageExpand
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Evolving roles of circadian rhythms in liver homeostasis and pathology
Circadian clock in mammals is determined by a core oscillator in the suprachiasmatic nucleus (SCN) of the hypothalamus and synchronized peripheral clocks in other tissues. The coherent timing systemsExpand
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H/ACA Box Small Nucleolar RNA 7A Promotes the Self‐Renewal of Human Umbilical Cord Mesenchymal Stem Cells
Human umbilical cord blood derived mesenchymal stem cells (uMSC) are pluripotent cells that have been now considered as a promising candidate for various cell‐based therapies. However, their limitedExpand
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