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- Publications
- Influence
Endogenous miRNA sponge lincRNA-RoR regulates Oct4, Nanog, and Sox2 in human embryonic stem cell self-renewal.
The embryonic stem cell (ESC) transcriptional and epigenetic networks are controlled by a multilayer regulatory circuitry, including core transcription factors (TFs), posttranscriptional modifier… Expand
MicroRNA-181 Regulates CARM1 and Histone Aginine Methylation to Promote Differentiation of Human Embryonic Stem Cells
- Zhenyu Xu, Junfeng Jiang, +4 authors H. Liu
- Biology, Medicine
- PloS one
- 3 January 2013
As a novel epigenetic mechanism, histone H3 methylation at R17 and R26, which is mainly catalyzed by coactivator-associated protein arginine methyltransferase 1 (CARM1), has been reported to modulate… Expand
LncRNA MALAT1 regulates oxLDL-induced CD36 expression via activating β-catenin.
- Ning Huangfu, Zhenyu Xu, Wenyuan Zheng, Y. Wang, Jingsong Cheng, X. Chen
- Chemistry, Medicine
- Biochemical and biophysical research…
- 15 January 2018
The expression of scavenger receptors in macrophages regulating lipid uptake plays an important role in foam cell formation and the subsequent atherosclerotic plaque formation. Long non-coding RNA… Expand
Potentiation of the anticancer effect of doxorubicinin drug-resistant gastric cancer cells by tanshinone IIA.
- Zhenyu Xu, Lu Chen, +11 authors J. Shen
- Chemistry, Medicine
- Phytomedicine : international journal of…
- 1 December 2018
BACKGROUND
Gastric cancer is the fifth commonest cancer and the third cause of cancer-related deaths all over the world. The effectiveness of chemotherapy is still limited by drug resistance in… Expand
Protective Role of mPGES-1 (Microsomal Prostaglandin E Synthase-1)–Derived PGE2 (Prostaglandin E2) and the Endothelial EP4 (Prostaglandin E Receptor) in Vascular Responses to Injury
- Huifeng Hao, S. Hu, +10 authors M. Wang
- Chemistry, Medicine
- Arteriosclerosis, thrombosis, and vascular…
- 2018
Objective— Deletion of mPGES-1 (microsomal prostaglandin E synthase-1)—an anti-inflammatory target alternative to COX (cyclooxygenase)-2—attenuates injury-induced neointima formation in mice. This is… Expand
Long non-coding RNA GAS5 controls human embryonic stem cell self-renewal by maintaining NODAL signalling
Long non-coding RNAs (lncRNAs) are known players in the regulatory circuitry of the self-renewal in human embryonic stem cells (hESCs). However, most hESC-specific lncRNAs remain uncharacterized.… Expand
Comprehensive molecular profiling of the B7 family of immune-regulatory ligands in breast cancer
- Zhenyu Xu, J. Shen, +12 authors Zhangang Xiao
- Medicine
- Oncoimmunology
- 11 July 2016
ABSTRACT The B7 gene family has crucial roles in the regulation of adaptive cellular immunity. In cancer, deregulation of co-inhibitory B7 molecules is associated with reduced antitumor immunity and… Expand
Macrophage polarization and function: new prospects for fibrotic disease
- Dexi Zhou, Kui Yang, +6 authors Jiajie Luan
- Biology, Medicine
- Immunology and cell biology
- 1 November 2017
Fibrosis is commonly regarded as a pathological and dynamic process with the hallmarks of chronic inflammation and wound healing. Emerging evidence indicates that heterogeneous monocyte–macrophage… Expand
Evolving roles of circadian rhythms in liver homeostasis and pathology
- Dexi Zhou, Y. Wang, +8 authors Jiajie Luan
- Biology, Medicine
- Oncotarget
- 28 January 2016
Circadian clock in mammals is determined by a core oscillator in the suprachiasmatic nucleus (SCN) of the hypothalamus and synchronized peripheral clocks in other tissues. The coherent timing systems… Expand
H/ACA Box Small Nucleolar RNA 7A Promotes the Self‐Renewal of Human Umbilical Cord Mesenchymal Stem Cells
Human umbilical cord blood derived mesenchymal stem cells (uMSC) are pluripotent cells that have been now considered as a promising candidate for various cell‐based therapies. However, their limited… Expand