Zhenxing Liu

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It is suspected that correlated motions among a subset of spatially separated residues drive conformational dynamics not only in multidomain but also in single domain proteins. Sequence and structure-based methods have been proposed to determine covariation between two sites on a protein. The statistical coupling analysis (SCA) that compares the changes in(More)
Quantitative description of how proteins fold under experimental conditions remains a challenging problem. Experiments often use urea and guanidinium chloride to study folding whereas the natural variable in simulations is temperature. To bridge the gap, we use the molecular transfer model that combines measured denaturant-dependent transfer free energies(More)
This paper proposes a hash-based secure interface between two nodes on the Internet, especial between two interfaces or two web pages. Digital signatures and public-private keys are traditionally used to provide integrity and authentication. This paper proposes an alternative method which uses a shared private key and a public hash function for a message(More)
Light is a very important regulator of the daily sleep rhythm. Here, we investigate the influence of nocturnal light stimulation on Drosophila sleep. Results showed that total daytime sleep was reduced due to a decrease in daytime sleep episode duration caused by discontinuous light stimulation, but sleep was not strongly impacted at nighttime although the(More)
A theoretical basis for the molecular transfer model (MTM), which takes into account the effects of denaturants by combining experimental data and molecular models for proteins, is provided. We show that the MTM is a mean field-like model that implicitly takes into account denaturant-induced many body interactions. The MTM in conjunction with the(More)
Little information is available on the prevalence, geographic distribution and mutation spectrum of genetic skeletal disorders (GSDs) in China. This study systematically reviewed GSDs as defined in "Nosology and Classification of genetic skeletal disorders (2010 version)" using Chinese biomedical literature published over the past 34 years from 1978 to(More)
1. CC-BY-NC-ND 4.0 International license peer-reviewed) is the author/funder. It is made available under a The copyright holder for this preprint (which was not. Abstract A major challenge in molecular simulations is to describe denaturant-dependent folding of proteins order to make direct comparisons with in vitro experiments. We use the molecular transfer(More)
This paper proposes a new Uniform Resource Identifier (URI) encoding scheme based on Base62x. URI is one of the base components of the Internet. URI is usually encoded in numerous applications for easy access. Current methods include encoding the URI with a percentage symbol followed by hexadecimal code (%hex) or the use of Base64. Deficiencies of existing(More)
OBJECTIVE To compare the efficacy and safety of high dose rate (HDR) and low dose rate (LDR) brachytherapy in treating early-stage oral cancer. DATA SOURCES A systematic search of MEDLINE, EMBASE and Cochrane Library databases, restricted to English language up to June 1, 2012, was performed to identify potentially relevant studies. STUDY SELECTION Only(More)