Zhenwu Kong

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The APC/C-Cdh1 ubiquitin-ligase complex targets cell cycle regulators for proteosomal degradation and helps prevent tumor development and accumulation of chromosomal aberrations. Replication stress has been proposed to be the main driver of genomic instability in the absence of Cdh1, but the real contribution of APC/C-Cdh1 to efficient replication,(More)
A series of β-elemene monosubstituted ester, carbamate, acylamide, and carbamidine derivatives were synthesized via intermediates, β-elemene alcohol and β-elemene amine, which were synthesized from the traditional Chinese medicine, β-elemene. The structures of all the new compounds were characterized by NMR, IR, and HRMS. Their in vitro antiproliferative(More)
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