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PDGF-mediated mesenchymal transformation renders endothelial resistance to anti-VEGF treatment in glioblastoma
TLDR
The authors demonstrate the role of PDGF signaling in GBM resistance to anti-VEGF treatment via a mechanism that involves endothelial-mesenchymal transformation and transcriptional regulation of VEGFR-2. Expand
Evaluation of cumulative prognostic score based on pretreatment plasma fibrinogen and serum albumin levels in patients with newly diagnosed high-grade gliomas
TLDR
Findings indicated that the pretreatment FA score could serve as a simple and noninvasive marker to predict the prognosis of patients with high-grade glioma. Expand
Zoledronic acid prevents the tumor-promoting effects of mesenchymal stem cells via MCP-1 dependent recruitment of macrophages
TLDR
This study found that ZA-treated mice showed a significant delay in tumor growth and demonstrated ZA can prevent the tumor-promoting effects of MSC, and decreased the infiltration of TAMs into tumor sites, and inhibited the tumor growth. Expand
Low preoperative prognostic nutritional index predicts poor survival in patients with newly diagnosed high-grade gliomas
TLDR
The PNI is a potentially valuable preoperative marker for the survival of patients following HGG resection and retained independent prognostic value in the validation set for both PFS and progression free survival. Expand
Bone metastasis predicts poor prognosis of patients with brain metastases from colorectal carcinoma post aggressive treatment
TLDR
Although the prognosis of CRC patients having BM is frequently very poor, those with good performance status and few brain lesions responded to aggressive treatment, while those with bone metastasis at the time of diagnosis of BM had relatively dismal survival rates, even when treated aggressively. Expand
Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α
TLDR
It is shown, in a mouse model of glioblastoma, that endothelial cells in the TME induce macrophage M2 polarization via IL-6 and that depletion of endothelial IL-8 improves survival, and it is suggested that targeting endothelialIL-6 may offer a selective and efficient therapeutic strategy for GBM, and possibly other solid malignant tumors. Expand
Xihuang Pill Induces Apoptosis of Human Glioblastoma U-87 MG Cells via Targeting ROS-Mediated Akt/mTOR/FOXO1 Pathway
TLDR
It is demonstrated for the first time that XHP may regulate glioblastoma U-87 MG cell apoptosis via ROS-mediated Akt/mTOR/FOXO1 pathway. Expand
Assessment of circulating tumor DNA in cerebrospinal fluid by whole exome sequencing to detect genomic alterations of glioblastoma
TLDR
Assessment of ctDNA in CSF by WES is a feasible approach to detect genomic alterations of glioblastoma, which may provide useful information for the decision of treatment strategy. Expand
Outcome of surgical resection for brain metastases and radical treatment of the primary tumor in Chinese non–small-cell lung cancer patients
TLDR
Surgical resection is an effective treatment for brain metastases and radical treatment of primary NSCLC was positively correlated with survival, and it was an independent prognostic factor in the multivariate analysis. Expand
Clinical significance of B7-H6 protein expression in astrocytoma
TLDR
The B7-H6 expression did not show significant relevance with patient age, sex distribution, Karnofsky performance status score, extent of resection, and tumor location in astrocytoma patients, but B7 -H6 positive expression is significantly associated with World Health Organization grade (P=0.046). Expand
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