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Apoptosis plays critical role in diabetic cardiomyopathy and endoplasmic reticulum stress (ERS) is one of intrinsic apoptosis pathways. For previous studies have shown that endoplasmic reticulum become swell in diabetic myocardium and ERS was involved in diabetes mellitus and heart failure, this study aimed to demonstrate whether ERS was induced in(More)
In Peer to Peer (P2P) systems, peers can join and leave the network whenever they want. Such " freedom " causes unpredictable network environment which leads to the most complex design challenge of a p2p protocol: how to make p2p service available under churn? What is more, where is the extreme of a system's resistibility to high churn? A careful evaluation(More)
Distinction between true protein interactions and crystal packing contacts is important for structural bioinformatics studies to respond to the need of accurate classification of the rapidly increasing protein structures. There are many unannotated crystal contacts and there also exist false annotations in this rapidly expanding volume of data. Previous(More)
Tagging systems are vulnerable to tag spam attacks. However, defending against tag spam has been challenging in practice, since adversaries can easily launch spam attacks in various ways and scales. To deeply understand users' tagging behaviors and explore more effective defense, this paper first conducts measurement experiments on public datasets of two(More)
Despite the increasing popularity, Internet video streaming to mobile devices is still challenging. In particular, there has been a format and resolution "gap" between Internet videos and mobile devices, so mobile users have high demand on video transcoding to facilitate their specific devices. However, as a computation-intensive work, video transcoding is(More)
Video content distribution dominates the Internet traffic. The state-of-the-art techniques generally work well in distributing popular videos, but do not provide satisfactory content distribution service for unpopular videos due to low data health or low data transfer rate. In recent years, the worldwide deployment of cloud utilities provides us with a(More)
As tools for personal storage, file synchronization and data sharing, cloud storage services such as Dropbox have quickly gained popularity. These services provide users with ubiquitous, reliable data storage that can be automatically synced across multiple devices, and also shared among a group of users. To minimize the network overhead, cloud storage(More)
Recent studies have begun to reveal critical roles of microRNAs (miRNAs) in the pathogenesis of cardiac hypertrophy and dysfunction. In this study, we tested whether a transforming growth factor-β (TGF-β)-regulated miRNA played a pivotal role in the development of cardiac hypertrophy and heart failure (HF). We observed that miR-27b was upregulated in hearts(More)