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A γ‐butyrolactone‐sensing activator/repressor, JadR3, controls a regulatory mini‐network for jadomycin biosynthesis
Two regulatory genes, jadR2 and jadR3, in the jadomycin (jad) biosynthetic gene cluster of Streptomyces venezuelae encode homologues of γ‐butyrolactone receptor. JadR2 was previously shown to be aExpand
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Kushneria sinocarnis sp. nov., a moderately halophilic bacterium isolated from a Chinese traditional cured meat.
A Gram-negative, aerobic, moderately halophilic bacterium, designated strain Z35T, was isolated from a Chinese traditional cured meat produced in Wuhan. The isolate grew with 1-20% NaCl (optimumExpand
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Recombineering in Streptococcus mutans Using Direct Repeat-Mediated Cloning-Independent Markerless Mutagenesis (DR-CIMM)
Studies of the dental caries pathogen Streptococcus mutans have benefitted tremendously from its sophisticated genetic system. As part of our own efforts to further improve upon the S. mutans geneticExpand
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JadR*‐mediated feed‐forward regulation of cofactor supply in jadomycin biosynthesis
Jadomycin production is under complex regulation in Streptomyces venezuelae. Here, another cluster‐situated regulator, JadR*, was shown to negatively regulate jadomycin biosynthesis by binding toExpand
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jadR* and jadR2 act synergistically to repress jadomycin biosynthesis
The biosynthesis of antibiotics is controlled by cascade regulation involving cluster-situated regulators (CSRs) and pleiotropic regulators. Three CSRs have been identified in the jadomycinExpand
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LytTR Regulatory Systems: A potential new class of prokaryotic sensory system
The most commonly studied prokaryotic sensory signal transduction systems include the one-component systems, phosphosignaling systems, extracytoplasmic function (ECF) sigma factor systems, and theExpand
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Pontibacillus yanchengensis sp. nov., a moderately halophilic bacterium isolated from salt field soil.
A Gram-positive-staining, aerobic, moderately halophilic bacterium, designated strain Y32(T), was isolated from subsurface soil of the Sanwei salt field, Yancheng, Jiangsu province, South-east China.Expand
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Pyruvate secretion by oral streptococci modulates hydrogen peroxide dependent antagonism
Many commensal oral streptococci generate H2O2 via pyruvate oxidase (SpxB) to inhibit the growth of competing bacteria like Streptococcus mutans, a major cariogenic species. In StreptococcusExpand
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Examining the Protein Interactome and Subcellular Localization of RNase J2 Complexes in Streptococcus mutans
Regulated RNA turnover is vital for the control of gene expression in all cellular life. In Escherichia coli, this process is largely controlled by a stable degradosome complex containing RNase E andExpand
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Regulatory control of the Streptococcus mutans HdrRM LytTR Regulatory System functions via a membrane sequestration mechanism
Bacteria sense and respond to environmental changes via several broad categories of sensory signal transduction systems. Recently, we described the key features of a previously unrecognized, butExpand