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A γ‐butyrolactone‐sensing activator/repressor, JadR3, controls a regulatory mini‐network for jadomycin biosynthesis
TLDR
The results revealed that the association of JadR3 and SVB1 plays an important role in controlling a regulatory mini‐network governing jadomycin biosynthesis, providing new insights into the ways in which γ‐butyrolactone/receptor systems modulate antibiotic biosynthesis in Streptomyces.
Kushneria sinocarnis sp. nov., a moderately halophilic bacterium isolated from a Chinese traditional cured meat.
TLDR
Based on the phenotypic, chemotaxonomic and phylogenetic evidence, strain Z35T is affiliated to Kushneria, but is clearly differentiated from other species of this genus and represents a new member, for which the name Kushneria sinocarnis sp.
JadR*‐mediated feed‐forward regulation of cofactor supply in jadomycin biosynthesis
TLDR
Results revealed that JadR* and early pathway intermediates, particularly DHR, regulate cofactor supply by a convincing case of a feed‐forward mechanism and delicate regulation of expression of jadY could ensure a timely supply of cofactors FMNH2/FADH2 for jadomycin biosynthesis, and avoid unnecessary consumption of NAD(P)H.
jadR* and jadR2 act synergistically to repress jadomycin biosynthesis
TLDR
The complex interactions among these three CSRs may provide clues for the activation of the jadomycin gene cluster, which would otherwise remain silent without stimulation from stress signals.
LytTR Regulatory Systems: A potential new class of prokaryotic sensory system
TLDR
Evidence is provided suggesting that LRS are a unique uncharacterized class of prokaryotic sensory system and a useful roadmap to investigate LRS function in the numerous other LRS-encoding organisms.
Recombineering in Streptococcus mutans Using Direct Repeat-Mediated Cloning-Independent Markerless Mutagenesis (DR-CIMM)
TLDR
A next-generation counterselection cassette is developed that eliminates 4-CP background resistance and combined with a new direct repeat-mediated cloning-independent markerless mutagenesis (DR-CIMM) system to specifically address the limitations of the prior approach.
Pyruvate secretion by oral streptococci modulates hydrogen peroxide dependent antagonism
TLDR
Targeted and transposon-based mutagenesis revealed Nox (putative H2O-forming NADH dehydrogenase) as an essential component required for pyruvate release and oxidative protection, while other genes such as sodA and dps play minor roles.
Pontibacillus yanchengensis sp. nov., a moderately halophilic bacterium isolated from salt field soil.
TLDR
A Gram-positive-staining, aerobic, moderately halophilic bacterium, designated strain Y32(T), was isolated from subsurface soil of the Sanwei salt field, Yancheng, Jiangsu province, South-east China and represents a novel member of the genus Pontibacillus.
Examining the Protein Interactome and Subcellular Localization of RNase J2 Complexes in Streptococcus mutans
TLDR
The results suggest that S. mutans degradosomes are either unlikely to exist or are quite distinct from those of E. coli, andRNase J2 exhibits multiple novel interactions that have not been previously reported for any RNase J proteins, some of which were highly biased for either the cytoplasmic or membrane fractions.
Regulatory control of the Streptococcus mutans HdrRM LytTR Regulatory System functions via a membrane sequestration mechanism
TLDR
The results indicate that sequestration of HdrR is likely to be the only mechanism required to inhibit its transcription regulator function, suggesting that endogenous activation of the HdrRM LRS is probably achieved through a modulation of theHdrR/M interaction.
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