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The goldfish optic nerve can regenerate after injury. To understand the molecular mechanism of optic nerve regrowth, we identified genes whose expression is specifically up-regulated during the early stage of optic nerve regeneration. A cDNA library constructed from goldfish retina 5 days after transection was screened by differential hybridization with(More)
Calreticulin-N58 (CRT-N58), an active fragment of calreticulin with anti-angiogenesis activity, was expressed in P. pastoris by high density cell culture. Calreticulin-N58 DNA was synthesized by PCR and cloned to plasmid pPIC9 K resulting in the plasmid pPIC9 K-crt-N58 which was then transformed into P. pastoris GS115. The fermentation was carried out in a(More)
The goldfish optic nerve regenerates after sectioning. Recently both short-term (30 days) and long-term (4 months) recovery of various goldfish behaviors were observed after optic nerve section. Using intracellular injection of Lucifer Yellow (LY) the morphology of regenerating ganglion cells in goldfish retina after optic nerve section over a 4 month(More)
A generic three-stage stack-and-draw method is demonstrated for the fabrication of complex-microstructured optical fibers. We report the fabrication and characterization of a silica superlattice microstructured fiber with more than 800 rhomboidally arranged air-holes. A polarization-maintaining fiber with a birefringence of 8.5 × 10 −4 is demonstrated. The(More)
We propose and demonstrate a highly sensitive in-line photonic crystal fiber (PCF) microfluidic refractometer. Ultrathin C-shaped fibers are spliced in-between the PCF and standard single-mode fibers. The C-shaped fibers provide openings for liquid to flow in and out of the PCF. Based on a Sagnac interferometer, the refractive index (RI) response of the(More)
We report an open-cavity optical fiber Fabry-Pérot interferometer (FPI) capable of measuring refractive index with very low temperature cross-sensitivity. The FPI was constructed by splicing a thin piece of C-shaped fiber between two standard single-mode fibers. The refractive index (RI) response of the FPI was characterized using water-ethanol mixtures(More)
A novel microfluidic flowmeter integrated with microfiber Bragg grating (µFBG) is presented. Two glass capillaries and a short length of high-light-absorption Co²⁺-doped optical fiber were stacked inside a larger outer capillary tube. The stack was then drawn into a tapered device. Two microchannels with the diameter of ~50  μm were formed inside the(More)
In this Letter, we reported on an ultrahigh birefringence photonic crystal fiber (PCF) with a germanium-doped elliptical core, which is fabricated in our lab using the stack-and-draw method. An ultrahigh birefringence of 1.1×10(-2) is obtained experimentally, which is close to the theoretical value of 1.4×10(-2) at the wavelength of 1550 nm. To our(More)
We have investigated the effect of free radicals on the electrical gap junctions between horizontal cells in the carp retina. In our previous study, L-buthionine sulfoximine, an inhibitor of glutathione synthesis, caused uncoupling of horizontal cells four days after injection. In the present study, we have used paraquat, a generator of exogenous reactive(More)
In this paper, we report a curvature sensor based on an LPG written in an air-clad thin-core fiber (AC-TCF). The achieved curvature sensitivity is &#x2212;0.226 nm/m<sup>&#x2212;1</sup> with a good linearity with R<sup>2</sup> value of 0.991. Unlike conventional LPGs, this AC-TCF LPG is insensitive to the variation of surrounding refractive index, due to(More)