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Obesity is rapidly becoming pandemic and is associated with increased carcinogenesis, especially hepatocellular carcinoma (HCC). Adipose tissue is considered as an endocrine organ because of its capacity to secrete a variety of adipokines, such as leptin, adiponectin and resistin. Recently, adipokines have been demonstrated to be associated with kinds of(More)
Peroxisome proliferator-activated receptor gamma (PPARgamma) coactivator-1 alpha (PGC-1alpha) coactivates multiple transcription factors and regulates several metabolic processes. The current study investigated the role of PGC-1alpha in the induction of apoptosis in human epithelial ovarian cancer cells. The PGC-1alpha mRNA level between human ovaries and(More)
Surgery following neoadjuvant chemoradiotherapy (NCRT) is a common multidisciplinary treatment for resectable esophageal cancer (EC). After analyzing 12 randomized controlled trials (RCTs), we discuss the key issues of surgery in the management of resectable EC. Along with chemoradiotherapy, NCRT is recommended for patients with squamous cell carcinoma(More)
OBJECTIVE To analyze the effects of number of positive lymph nodes and metastatic lymph node ratio (LNR) in evaluation of recurrence risk and overall survival in patients with adenocarcinoma of the esophagogastric junction (AEG) after curative resection. METHODS Clinical data of 337 AEG patients who underwent curative resection in our hospital were(More)
OBJECTIVE To explore the effect of HMGB1 on the VEGF-C expression and proliferation of esophageal squamous cancer cells as well as its possible mechanism. METHODS A cassette encoding siRNA targeting HMGB1 mediated by rAAV was constructed, the rAAV-siHMGB1-hrGFP, and a vector encoding siRNA mismatching HMGB1 was constructed, the rAAV-miHMGB1-hrGFP. This(More)
The purpose of this study is to investigate the biocompatibility and osteoconduction of active porous calcium-phosphate films on the novel Ti-3Zr-2Sn-3Mo-25Nb biomedical alloy. The active porous calcium-phosphate films were prepared by the micro-arc oxidation method on the surface of a near β biomedical Ti-3Zr-2Sn-3Mo-25Nb alloy, and then activated in a(More)
BACKGROUND Postoperative radiotherapy (PORT) for thymic tumor is still controversial. The object of the study is to evaluate the role of PORT for stage I to III thymic tumors. METHODS The Chinese Alliance for Research in Thymomas (ChART) was searched for patients with stage I to III thymic tumors who underwent surgical resection without neoajuvant therapy(More)
Rotary clock is a multi-gigahertz clock distribution technique based on the principle of wave propagation in transmission lines. In this paper, we perform the first quantitative investigation on the power dissipation of rotary clock designs. Specifically, we have developed a software tool based on the method of partial element equivalent circuit (PEEC) that(More)
Rotary clock technique has been shown to reduce the power dissipation of clock distribution by up to 80%. However, to our knowledge, no practical digital synchronous circuit has been designed that utilizes the rotary technique due to the multi-phase nature of rotary clock signals and the strong coupling between a rotary clock network and the circuit it(More)