Learn More
Under the guidance of bioassay, the EtOAc extract fraction of the Traditional Chinese Medicine (TCM) Galla Chinese was found to be efficient in inhibiting the NS3 protease of HCV and purified the fraction to get three polyphenol compounds 1,2,6-tri-O-galloyl-beta-D-glucose (1), 1,2,3,6-tetra-O-galloyl-beta-D-glucose (2), and(More)
Severe acute respiratory syndrome coronavirus (SARS-CoV) is the pathogen of SARS, which caused a global panic in 2003. We describe here the screening of Chinese herbal medicine-based, novel small molecules that bind avidly with the surface spike protein of SARS-CoV and thus can interfere with the entry of the virus to its host cells. We achieved this by(More)
Treatment of the chronic hepatitis C virus (HCV) infection is an unmet medical need, and the HCV NS3 serine protease (NS3-SP) has been used as an attractive target of antiviral screening against HCV. To find naturally chemical entities as lead compounds from which novel anti-HCV agents could be developed, bioassay-guided fractionation and isolation were(More)
Hexagonal-phase NaYF(4):Yb, Er/Tm nanocrystals are the best IR-to-visible upconverting materials to date, but user-friendly methods for making pure hexagonal-phase NaYF(4):Yb, Er/Tm nanocrystals with upconversion fluorescence are still lacking. Most of the methods reported so far require excess fluoride reactants in a high-temperature reaction which are(More)
  • Niagara Muhammad Idris, Zhengquan Li, +4 authors Yong Zhang
  • 2009
With the emergence of cell transplant as an attractive treatment modality for various diseases, there is a parallel need to track the fate of these cells to assess their therapeutic effectiveness. Here, we report the use of upconversion fluorescent nanoparticles, silica/NaYF(4):Yb,Er, to dynamically track live myoblast cells in vitro and in a living mouse(More)
Rare-earth upconversion nanophosphors (UCNPs) have great potential to become excellent biological luminescent labels for fluorescence bioimaging. However, it is still difficult to directly synthesize high-quality water-soluble UCNPs bearing appropriate functional groups using a one-step synthetic strategy. Herein, we report a one-step synthetic strategy for(More)
A new coordination-polymer-precursor route has been developed to synthesize nanowires under hydrothermal conditions. In the present work, well-aligned gamma-MnO(2) nanowires, growing along the [0 0 2] axis, have successfully been prepared by selecting an appropriate coordination polymer [[Mn(SO(4))(4,4'-bpy)(H(2)O)(2)](n)] as precursor. In comparison with(More)
Because of the limited penetration depth of visible light that generally excites most of the available photosensitizers (PSs), conventional photodynamic therapy (PDT) is limited to the treatment of superficial and flat lesions. Recently, the application of deep penetrating near-infrared (NIR) light excitable upconversion nanoparticles (UCNs) in conjunction(More)
The induction of autophagy on exposure of cells to a variety of nanoparticles represents both a safety concern and an application niche for engineered nanomaterials. Here, we show that a short synthetic peptide, RE-1, identified by means of phage display, binds to lanthanide (LN) oxide and upconversion nanocrystals (UCN), forms a stable coating layer on the(More)