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A derivative of betulinic acid protects human Retinal Pigment Epithelial (RPE) cells from cobalt chloride‐induced acute hypoxic stress
TLDR
This BA derivate has protective effect against the acute hypoxic stress in human RPE cells and may be developed into a candidate agent effective in the prevention of prevalent retinal diseases. Expand
The 5′-AMP-Activated Protein Kinase Regulates the Function and Expression of Human Organic Anion Transporting Polypeptide 1A2
TLDR
Overall, this study implicated AMPK in the regulation of the function and expression of OATP1A2, which potentially impacts on the disposition of Oatin 1A2 drug substrates that may be used to treat patients with the metabolic syndrome and other diseases. Expand
Demonstration of In Vitro Host-Guest Complex Formation and Safety of para-Sulfonatocalix[8]arene as a Delivery Vehicle for Two Antibiotic Drugs.
TLDR
The results showed that sCX[8], the macrocycle para-sulfonatocalix[8]arene, has no inherent antibiotic activity and had no negative effect on the action of ciprofloxacin and isoniazid. Expand
Betulinic acid derivatives can protect human Müller cells from glutamate-induced oxidative stress.
TLDR
The BA analogues H3, H5 and H7 are protective against glutamate-induced oxidative stress in human Müller cells, and elicit their actions by modulation of the Erk, Akt and JNK signaling pathways. Expand
The Potential Application of Pentacyclic Triterpenoids in the Prevention and Treatment of Retinal Diseases.
TLDR
The present literature supports the further development of pentacyclic triterpenoids and future research should now attempt to improve the efficacy and pharmacokinetic behaviour of the agents, possibly by the use of medicinal chemistry and targeted drug delivery strategies. Expand
The involvement of human organic anion transporting polypeptides (OATPs) in drug-herb/food interactions
TLDR
This review summarises the drug-herb/food interactions of drugs and chemicals that are present in herbal medicines and/or food in relation to human OATPs to contribute to improving clinical outcomes and avoiding unexpected toxicities of drug therapies in patients. Expand
Procyanidin B2 and rutin in Ginkgo biloba extracts protect human retinal pigment epithelial (RPE) cells from oxidative stress by modulating Nrf2 and Erk1/2 signalling.
TLDR
The present findings suggest that rutin and procyanidin B2 may have potential therapeutic values in the prevention of retinal diseases induced by oxidative damage. Expand
' s response to reviews Title : Hit Identification of IKK-beta Natural Product Inhibitor
We are pleased to note that the Reviewer 1 recognized our manuscript to be “well-written and well-structured and is an interesting field of research and it could contribute positively to theExpand
Impaired transport activity of human Organic anion transporters (OATs) and Organic anion transporting polypeptides (OATPs) by Wnt inhibitors.
TLDR
It is suggested that Wnt inhibitors selectively modulate the function of multiple organic anions transporters, so their clinical use may have unanticipated effects on drug entry into cells. Expand