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BACKGROUND An effective, systematic program of screening, diagnosis and intervention against hearing loss in infants could help them avoid developmental impediments and could help society stem preventable healthcare burdens. We assessed the feasibility and outcomes of a new public health universal newborn hearing screening program (UNHSP) for neonates born(More)
PTEN acts as a phosphatidylinositol phosphatase with a possible role in the phosphatidylinositol 3-kinase (PI3K)/AKT pathway. Mutations in PTEN are frequent and their presence is associated with poor prognosis in breast cancer, which is the most common type of non-cutaneous malignancy in females. Delivery of the tumor suppressor PTEN gene represents a(More)
Cell-penetrating peptides (CPPs) are non-invasive vectors that can efficiently transport bioactive cargo across the cell membrane. Naturally occurring CPPs, such as the tegu-ment protein VP22 of the Herpes simplex virus type 1, can potentiate protein‑drug delivery into living cells. The aim of the present study was to construct anti‑VP22 antibodies that can(More)
Accurate flood routing is essential for flood control in water resources planning and management. The Muskingum model continues to be popular method for flood routing. Its parameter estimation is a global optimization problem with the main objective to find a set of optimal model parameter values that attains a best fit between observed and computed flow.(More)
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