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The nuclear enzyme poly (ADP ribose) synthetase (PARS) has been shown to play an important role in the pathogenesis of various forms of ischemia or reperfusion injury and circulatory shock. Recent studies demonstrated that inhibition or genetic inactivation of PARS is beneficial in the early phase of myocardial reperfusion injury. The aim of the present(More)
BACKGROUND Activation of the nuclear enzyme poly (ADP-ribose) synthetase (PARS) in response to oxidant-mediated DNA injury has been shown to play an important role in the pathogenesis of reperfusion injury. Here we investigated the role of PARS in myocardial ischemic preconditioning (IPC). MATERIALS AND METHODS Mice with or without genetic disruption of(More)
BACKGROUND The anti-inflammatory cytokine interleukin-10 (IL-10) has been detected in the plasma of patients with myocardial ischemia/reperfusion. The aim of our study was to investigate the role of endogenously produced IL-10 in myocardial ischemia/reperfusion. METHODS AND RESULTS In the present study, we used wild-type and IL-10-deficient mice subjected(More)
BACKGROUND Interleukin 10 (IL-10) exerts a wide spectrum of regulatory activities in immune and inflammatory responses. AIMS The aim of this study was to investigate the role of endogenous IL-10 on modulation of the early inflammatory response after splanchnic ischaemia and reperfusion. METHODS Intestinal damage was induced by clamping the superior(More)
Interleukin (IL)-12 is a heterodimeric cytokine that is secreted mainly by antigen-presenting cells and plays a key role in determining the nature of immune response to exogenous or endogenous antigens. Negative regulators of IL-12 production include IL-10. With use of wild-type and IL-10-deficient mice, the aim of the current investigation was to determine(More)
OBJECTIVES To investigate the best time of examination and section chosen of routine prenatal ultrasound screening for external ear abnormalities and evaluate the feasibility of examining the fetal external ear with ultrasonography. METHODS From July 2010 until August 2011, 42118 pregnant women with single fetus during 16-40 weeks of pregnancy were(More)
The molybdenum disulfide/reduced graphene oxide@polyaniline (MoS2/RGO@PANI) was facilely and effectively prepared through a two-stage synthetic method including hydrothermal and polymerized reactions. The rational combination of two components allowed polyaniline (PANI) to uniformly cover the outer face of molybdenum disulfide/reduced graphene oxide(More)
A carbon/SnO(2)/carbon core/shell/shell hybrid nanofibrous mat was successfully prepared via single-spinneret electrospinning followed by carbonization and hydrothermal treatment. The morphology and structure of carbon/SnO(2)/carbon hybrid nanofibers were characterized by field-emission scanning electron microscopy, transmission electron microscopy,(More)
Large-area and highly crystalline monolayer molybdenum disulfide (MoS2) with a tunable grain size was synthesized in a H2 atmosphere. The influence of introduced H2 on MoS2 growth and grain size, as well as the corresponding mechanism, was tentatively explored by controlling the H2 flow rate. The as-grown monolayer MoS2 displays excellent uniformity and(More)
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