Zheng-xin Yang

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OBJECTIVE To study the effect of SiRNA-EGFR on the expression of hyaluronidase gene in human breast cancer cells. METHODS Reverse transcription-polymerse chain reaction was used to detect the changes in the expression of EGFR mRNA in human breast cancer cell lines MDA-MB-231, MDA-MB-435S, ZR-75 and ZR-75-30 after transfection by SiRNA-EGFR. RESULTS(More)
OBJECTIVE To investigate the effect of cationic liposome-mediated RNA interference (RNAi) in silencing epidermal growth factor (EGF) receptor (EGFR) gene in breast cancer cells in vivo. METHODS A small interfering RNA (siRNA) targeting EGFR gene was constructed and transfected into human breast cancer cell in vitro via cationic liposome. The transfected(More)
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