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- Publications
- Influence
TAZ Promotes Cell Proliferation and Epithelial-Mesenchymal Transition and Is Inhibited by the Hippo Pathway
ABSTRACT TAZ is a WW domain containing a transcription coactivator that modulates mesenchymal differentiation and development of multiple organs. In this study, we show that TAZ is phosphorylated by… Expand
TEAD Transcription Factors Mediate the Function of TAZ in Cell Growth and Epithelial-Mesenchymal Transition*
- Heng Zhang, Chen-Ying Liu, +6 authors K. Guan
- Biology, Medicine
- Journal of Biological Chemistry
- 15 May 2009
The TAZ transcription co-activator has been shown to promote cell proliferation and to induce epithelial-mesenchymal transition. Recently we have demonstrated that TAZ is phosphorylated and inhibited… Expand
The Hippo Tumor Pathway Promotes TAZ Degradation by Phosphorylating a Phosphodegron and Recruiting the SCFβ-TrCP E3 Ligase*
- Chen-Ying Liu, Zheng-Yu Zha, +11 authors K. Guan
- Biology, Medicine
- The Journal of Biological Chemistry
- 21 September 2010
The TAZ transcription co-activator promotes cell proliferation and epithelial-mesenchymal transition. TAZ is inhibited by the Hippo tumor suppressor pathway, which promotes TAZ cytoplasmic… Expand
Correction: TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition.
- H. Zhang, Chen-Ying Liu, +6 authors K. Guan
- Medicine
- The Journal of Biological Chemistry
- 12 April 2019
Correction: TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. Heng Zhang, Chen-Ying Liu, Zheng-Yu Zha, Bin Zhao, Jun Yao, Shimin Zhao, Yue… Expand
Deglycosylation of PD-L 1 by 2-deoxyglucose reverses PARP inhibitor-induced immunosuppression in triple-negative breast cancer
- B. Shao, C. Li, +12 authors Mien-Chie Hung
- 2018
Triple-negative breast cancer (TNBC), the most difficult-to-treat breast cancer subtype, lacks well-defined molecular targets. TNBC has increased programmed death-ligand 1 (PD-L1) expression, and its… Expand