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When a D-brane wraps around a cycle of a curved manifold, the twisting of its normal bundle can induce chiral asymmetry in its world-volume theory. We obtain the general form of the resulting anomalies for D-branes and their intersections. They are not cancelled among themselves, and the standard inflow mechanism does not apply at first sight because of(More)
We use brane configurations and SL(2, Z) symmetry of the type IIB string to construct mirror N = 2 supersymmetric gauge theories in three dimensions. The mirror map exchanges Higgs and Coulomb branches, Fayet-Iliopoulos and mass parameters and U(1) R symmetries. Some quantities that are determined at the quantum level in one theory are determined at the(More)
We derive in the SCFT and low energy eeective action frameworks the necessary and suucient conditions for supersymmetric cycles in exceptional holonomy manifolds and Calabi-Yau 4-folds. We show that the Cayley cycles in Spin(7) holonomy eight-manifolds and the associative and coassociative cycles in G 2 holonomy seven-manifolds preserve half of the(More)
The introduction of Lipinski's 'Rule of Five' has initiated a profound shift in the thinking paradigm of medicinal chemists. Understanding the difference between biologically active small molecules and drugs became a priority in the drug discovery process, and the importance of addressing pharmacokinetic properties early during lead optimization is a clear(More)
1 The objective of this research project is to propose a Web services oriented framework for e-learning systems aimed at providing a flexible integration model in which all the learning components and applications are well defined, effectively discovered and loosely connected. Web services provide an essential deploy environment to realize dynamic(More)
Genetic Programming (GP) is an automated computational programming methodology, inspired by the workings of natural evolution techniques. It has been applied to solve complex problems in multiple domains including finance. This paper illustrates the application of an adaptive form of GP, where the probability of crossover and mutation is adapted dynamically(More)
Adipose-resident T cells (ARTs) regulate metabolic and inflammatory responses in obesity, but ART activation signals are poorly understood. Here, we describe class II major histocompatibility complex (MHCII) as an important component of high-fat-diet (HFD)-induced obesity. Microarray analysis of primary adipocytes revealed that multiple genes involved in(More)
Crystal structure analysis of Flavivirus methyltransferases uncovered a flavivirus-conserved cavity located next to the binding site for its cofactor, S-adenosyl-methionine (SAM). Chemical derivatization of S-adenosyl-homocysteine (SAH), the product inhibitor of the methylation reaction, with substituents that extend into the identified cavity, generated(More)
We study the large N limit of the interacting superconformal field theories associated with N M5 branes or M2 branes using the recently proposed relation between these theories and M theory on AdS spaces. We first analyze the spectrum of chiral operators of the 6d (0, 2) theory associated with M5 branes in flat space, and find full agreement with earlier(More)