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The extent to which variation in chromatin structure and transcription factor binding may influence gene expression, and thus underlie or contribute to variation in phenotype, is unknown. To address this question, we cataloged both individual-to-individual variation and differences between homologous chromosomes within the same individual (allele-specific(More)
H1 linker histones facilitate higher-order chromatin folding and are essential for mammalian development. To achieve high-resolution mapping of H1 variants H1d and H1c in embryonic stem cells (ESCs), we have established a knock-in system and shown that the N-terminally tagged H1 proteins are functionally interchangeable to their endogenous counterparts in(More)
Inositol-requiring enzyme 1 (IRE1) is the most highly conserved signaling node of the unfolded protein response (UPR) and represents a potential therapeutic target for a number of diseases associated with endoplasmic reticulum stress. IRE1 activates the XBP-1 transcription factor by site-specific cleavage of two hairpin loops within its mRNA to facilitate(More)
When schedules of several operant trials must be successfully completed to obtain a reward, monkeys quickly learn to adjust their behavioral performance by using visual cues that signal how many trials have been completed and how many remain in the current schedule. Bilateral rhinal (perirhinal and entorhinal) cortex ablations irreversibly prevent this(More)
a grant from the Obayashi Corporation (Japan) to the third author. We would like to thank the students, faculty and mentors of Stanford University's CEE222 class for their participation in the " Trust in Global Teams " research project. Abstract With Internet technology and globalization, companies are rapidly adopting cross-functional, global teams, but(More)
a r t i c l e i n f o In this paper, we propose a learning-based super resolution approach consisting of two steps. The first step uses the kernel partial least squares (KPLS) method to implement the regression between the low-resolution (LR) and high-resolution (HR) images in the training set. With the built KPLS regression model, a primitive(More)