Learn More
The effect of unilateral depletion of retinal dopamine on goldfish visual behavior was studied using a behavioral reflex, the dorsal light reaction (DLR). Retinal dopamine was depleted by intraocular injections of 6-hydroxydopamine (6-OHDA) on two successive days. By 2 weeks postinjection, dopamine interplexiform cells (DA-IPC) were not detected using(More)
Lmx1a is a LIM homeodomain-containing transcription factor, which is required for the formation of multiple organs. Lmx1a is broadly expressed in early stages of the developing inner ear, but its expression is soon restricted to the non-sensory regions of the developing ear. In an Lmx1a functional null mutant, dreher (dr(J)/dr(J)), the inner ears lack a(More)
Increment threshold functions of the electroretinogram (ERG) b-wave were obtained from goldfish using an in vivo preparation to study intraretinal mechanisms underlying the increase in perceived brightness induced by depletion of retinal dopamine by 6-hydroxydopamine (6-OHDA). Goldfish received unilateral intraocular injections of 6-OHDA plus pargyline on(More)
The possibility of GABAA receptor heterogeneity in goldfish retina was studied with immunocytochemical and biochemical approaches: 1) immunoblotted membrane particulates of goldfish retina with mAb 62-3G1; 2) immunoprecipitation of the detergent-solubilized membrane proteins with mAb 62-3G1 followed by the receptor binding assay; 3) photoaffinity labeling(More)
In this paper, we aim to jointly extract aspects and aspect-specific sentiment knowledge from online reviews, where the sentiment knowledge refers to the aspect-specific opinion words along with their aspect-aware sentiment polarities. To this end, we propose a Joint Aspect/Sentiment model (JAS). JAS detects aspect-specific opinion words by integrating(More)
We study the role of the diffusive interaction in plankton dynamics in a patchy environment. We use a minimal reaction-diffusion model of the nutrient-plankton-fish food chain to simulate the diffusive interaction between fish-populated and fish-free habitats. We show that such interaction can give rise to spatiotemporal plankton patterns. The plankton(More)
The serine/threonine phosphatase protein phosphatase 2A (PP2A) plays an essential role in many aspects of cellular functions and has been shown to be an important tumor suppressor. The core enzyme of PP2A comprises a 65 kDa scaffolding subunit and a 36 kDa catalytic subunit. Here we report the crystal structures of the PP2A core enzyme bound to two of its(More)
Protein Phosphatase 2A (PP2A) plays an essential role in many aspects of cellular physiology. The PP2A holoenzyme consists of a heterodimeric core enzyme, which comprises a scaffolding subunit and a catalytic subunit, and a variable regulatory subunit. Here we report the crystal structure of the heterotrimeric PP2A holoenzyme involving the regulatory(More)