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The prevalent DNA modification in higher organisms is the methylation of cytosine to 5-methylcytosine (5mC), which is partially converted to 5-hydroxymethylcytosine (5hmC) by the Tet (ten eleven translocation) family of dioxygenases. Despite their importance in epigenetic regulation, it is unclear how these cytosine modifications are reversed. Here, we(More)
Recovery from intrusions is typically a very time-consuming operation in current systems. At a time when the cost of human resources dominates the cost of computing resources, we argue that next generation systems should be built with automated intrusion recovery as a primary goal. In this paper, we describe the design of Taser, a system that helps in(More)
Beta-catenin is upregulated in many human cancers and considered to be an oncogene. Hepatocellular carcinoma (HCC) is one of the most prevalent human malignancies, and individuals who are chronic hepatitis B virus (HBV) carriers have a greater than 100-fold increased relative risk of developing HCC. Here we report a mechanism by which HBV-X protein (HBX)(More)
While transistor performance and energy efficiency have dramatically improved in recent years, electrical interconnect improvements has failed to keep pace. Recent advances in nanophotonic fabrication have made on-chip optics an attractive alternative. However, system integration challenges remain. In particular, the parameters of on-chip nanophotonic(More)
Web services are designed for composition and use by third parties through dynamic discovery. As such, the issue of interoperability between services is of great importance to ensure that the services can work together towards the overall application goals. In particular, the interaction protocols of a service need to be implemented and used properly so(More)
DNA hydroxymethylation and its mediated DNA demethylation are critical for multiple cellular processes, for example, nuclear reprogramming, embryonic development, and many diseases. Here, we demonstrate that a vital nutrient ascorbic acid (AA), or vitamin C (Vc), can directly enhance the catalytic activity of Tet dioxygenases for the oxidation of(More)
Hickory (Carya cathayensis Sarg.) is an economically important woody plant in China, but its long juvenile phase delays yield. MicroRNAs (miRNAs) are critical regulators of genes and important for normal plant development and physiology, including flower development. We used Solexa technology to sequence two small RNA libraries from two floral(More)
In this paper, we propose a simple orthogonal space time transmission scheme for asynchronous cooperative systems. In the proposed scheme, OFDM is implemented at the source node, some very simple operations, namely time reversion and complex conjugation, are implemented at the relay nodes, and a two-step of cyclic prefix (CP) removal is performed at the(More)