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The prevalent DNA modification in higher organisms is the methylation of cytosine to 5-methylcytosine (5mC), which is partially converted to 5-hydroxymethylcytosine (5hmC) by the Tet (ten eleven translocation) family of dioxygenases. Despite their importance in epigenetic regulation, it is unclear how these cytosine modifications are reversed. Here, we(More)
Beta-catenin is upregulated in many human cancers and considered to be an oncogene. Hepatocellular carcinoma (HCC) is one of the most prevalent human malignancies, and individuals who are chronic hepatitis B virus (HBV) carriers have a greater than 100-fold increased relative risk of developing HCC. Here we report a mechanism by which HBV-X protein (HBX)(More)
Recovery from intrusions is typically a very time-consuming operation in current systems. At a time when the cost of human resources dominates the cost of computing resources, we argue that next generation systems should be built with automated intrusion recovery as a primary goal. In this paper, we describe the design of Taser, a system that helps in(More)
While transistor performance and energy efficiency have dramatically improved in recent years, electrical interconnect improvements has failed to keep pace. Recent advances in nanophotonic fabrication have made on-chip optics an attractive alternative. However, system integration challenges remain. In particular, the parameters of on-chip nanophotonic(More)
Following differential screening of gene expression during tomato fruit development, we isolated developmentally regulated (DR) clones, including several putative transcription factors. Based on sequence homology, DR1, DR3, DR4 and DR8 are members of the Aux/IAA family, and DR12 belongs to the auxin response factor (ARF) family of transcription factors.(More)
Web services are designed for composition and use by third parties through dynamic discovery. As such, the issue of interoperability between services is of great importance to ensure that the services can work together towards the overall application goals. In particular, the interaction protocols of a service need to be implemented and used properly so(More)
In this paper, we propose a simple orthogonal space time transmission scheme for asynchronous cooperative systems. In the proposed scheme, OFDM is implemented at the source node, some very simple operations, namely time reversion and complex conjugation, are implemented at the relay nodes, and a two-step of cyclic prefix (CP) removal is performed at the(More)
In this study, we investigated the essential criteria for late-onset hypogonadism (LOH) syndrome based on the presence of symptoms associated with low testosterone levels in Han Chinese men. Blood tests for total testosterone (TT) and sex hormone-binding globulin (SHBG) were performed, and the aging male symptoms (AMS) questionnaire was conducted in a(More)