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We formulate and analyze an optimal stopping problem concerning a terrorist who is attempting to drive a nuclear or radiological weapon toward a target in a city center. In our model, the terrorist needs to travel through a two-dimensional lattice containing imperfect radiation sensors at some of the nodes, and decides at each node whether to detonate the(More)
By interacting with the cytoplasmic tail of a Golgi-processed form of transforming growth factor-alpha (TGFalpha), Naked2 coats TGFalpha-containing exocytic vesicles and directs them to the basolateral corner of polarized epithelial cells where the vesicles dock and fuse in a Naked2 myristoylation-dependent manner. These TGFalpha-containing(More)
  • Zheng Cao, Benjamin T. Moore, Yang Wang, Xian-Hao Peng, Joan M. Lappe, Robert R. Recker +1 other
  • 2014
BACKGROUND MicroRNAs (miRNAs) are a class of short non-coding RNA molecules that regulate gene expression by targeting mRNAs. Recently, miRNAs have been shown to play important roles in the etiology of various diseases. However, little is known about their roles in the development of osteoporosis. Circulating monocytes are osteoclast precursors that also(More)
Activation-induced deaminase (AID) deaminates cytosine to uracil in immunoglobulin genes. Uracils in DNA can be recognized by uracil DNA glycosylase and abasic endonuclease to produce single-strand breaks. The breaks are repaired either faithfully by DNA base excision repair (BER) or mutagenically to produce somatic hypermutation (SHM) and class switch(More)
We propose an AWGR-based scalable optical direct interconnect architecture exploiting a flat distributed Thin-CLOS topology at the core-layer. The architecture scales beyond 100,000 nodes with a diameter of 7, low latency, high degree and throughput. 1. Introduction The demand for low latency, high-throughput, and scalable communications in data centers and(More)
Low-fidelity DNA polymerases introduce nucleotide substitutions in immunoglobulin variable regions during somatic hypermutation. Although DNA polymerase (pol) η is the major low-fidelity polymerase, other DNA polymerases may also contribute. Existing data are contradictory as to whether pol ζ is involved. We reasoned that the presence of pol η may mask the(More)
A bilayered construct with or without adipose-derived stem cells (ASCs) was applied to repair full-thickness defects in the patellar groove of 18 rabbits. Non-treated and treated defects were divided into three groups: a control group (n = 12), a cell-free group (n = 12) and a cell-based group (n = 12). Histological appearance and grading were evaluated at(More)