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The fundamental feature of an OpenFlow network is that the controller is responsible for the initial establishment of every flow by contacting related switches. Thus the performance of the controller could be a bottleneck. This paper shows how this fundamental problem is addressed by parallelism. The state of the art OpenFlow controller, called NOX,(More)
We present Tesseract, an experimental system that enables the direct control of a computer network that is under a single administrative domain. Tesseract's design is based on the 4D architecture, which advocates the decomposition of the network control plane into decision, dissemination, discovery, and data planes. Tesseract provides two primary abstract(More)
Network operation is inherently complex because it consists of many functions such as routing, firewalling, VPN provisioning, traffic load-balancing, network maintenance , etc. To cope with this, network designers have created modular components to handle each function. Unfortunately , in reality, unavoidable dependencies exist between some of the(More)
The fundamental feature of an OpenFlow network is that the controller is responsible for the configuration of switches for every traffic flow. This feature brings programmability and flexibility, but also puts the controller in a critical role in the performance of an Open-Flow network. To fairly service requests from different switches, to achieve low(More)
—This paper presents the CONTRACT framework to address a fundamental deficiency of the IP network control plane, namely the lack of coordination between an IGP and other control functions involved in achieving a high level objective. For example, an IGP's default automatic reaction to a network failure may result in an SLA violation, even if the IGP link(More)
We applied a shared genomic segment (SGS) analysis, incorporating an error model, to identify complete, or near complete, selective sweeps in the HapMap phase II data sets. This method is based on detecting heterozygous sharing across all individuals within a population, to identify regions of sharing with at least one allele in common. We identified(More)
We applied our method of pairwise shared genomic segment (pSGS) analysis to high-risk pedigrees identified from the Genetic Analysis Workshop 17 (GAW17) mini-exome sequencing data set. The original shared genomic segment method focused on identifying regions shared by all case subjects in a pedigree; thus it can be sensitive to sporadic cases. Our new(More)
Src family kinases regulate neuronal voltage-gated Na+ channels, which generate action potentials. The mechanisms of action, however, remain poorly understood. The aim of the present study was to further elucidate the effects of Src family kinases on Nav1.1 mRNA and protein expression in spiral ganglion neurons. Immunofluorescence staining techniques(More)
Our previous study showed that RalA-binding protein 1 (RLIP76) is overexpressed in gliomas and is associated with higher tumour grade and decreased patient survival. Furthermore, RLIP76 downregulation increases chemosensitivity of glioma cells to temozolomide by inducing apoptosis. However, other mechanisms underlying RLIP76-associated chemoresistance are(More)
OBJECTIVE To investigate mRNA expression of GABAa receptor(GABAaR) subunits in the rat cochlear spiral ganglion neurons (SGN) and explore the effect of sodium salicylate (SS) on the expression of GABAaR subunits. METHOD The realtime fluorescent quantitative PCR (FQ-PCR) was used to detect mRNA expression of twelve GABAaR subunits in the newborn rat SGN(More)