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" Certificateless public-key cryptosystem " is a new and attractive paradigm, which avoids the inherent key escrow property in identity-based public-key cryptosystems, and does not need expensive certificates as in the public key infrastructure. A strong security model for certificateless public key encryption was established by Al-Riyami and Paterson in(More)
Human non-small cell lung cancers (NSCLCs) with activating mutations in EGFR frequently respond to treatment with EGFR-targeted tyrosine kinase inhibitors (TKIs), such as erlotinib, but responses are not durable, as tumors acquire resistance. Secondary mutations in EGFR (such as T790M) or upregulation of the MET kinase are found in over 50% of resistant(More)
Transforming growth factor-beta (TGF-beta) plays a dual and complex role in human cancer. In this report, we observe a specific set of MicroRNAs (miRNAs) changed in response to TGF-beta in human hepatocellular carcinoma (HCC) cells by miRNA microarray screening. A cluster of miRNA, miR-23a approximately 27a approximately 24, is induced in an early stage by(More)
UNLABELLED The pathological relevance and significance of microRNAs (miRNAs) in hepatocarcinogenesis have attracted much attention in recent years; however, little is known about the underlying molecular mechanisms through which miRNAs are involved in the development and progression of hepatocellular carcinoma (HCC). In this study, we demonstrate that(More)
Mitogen-activated protein kinase (MAPK) pathway signaling plays an important role in the majority of non-small-cell lung cancers (NSCLCs). In a prior microarray analysis of epidermal growth factor receptor (EGFR) inhibition in NSCLC cell lines, we noted that several dual specificity phosphatases (DUSPs) were among the most highly and immediately regulated(More)
The development of EGFR tyrosine kinase inhibitors for clinical use in non-small cell lung cancer and the subsequent discovery of activating EGFR mutations have led to an explosion of knowledge in the fields of EGFR biology, targeted therapeutics and lung cancer research. EGFR-mutated adenocarcinoma of the lung has clearly emerged as a unique clinical(More)
Identity-based (ID-based) public key cryptosystem can be a good alternative for certificate-based public key setting, especially when efficient key management and moderate security are required. A proxy signature scheme permits an entity to delegate its signing rights to another entity. But to date, no ID-based proxy signature scheme with prov-able security(More)
In this paper, we present a practical and provably secure two-pass AKE protocol from ideal lattices, which is conceptually simple and has similarities to the Diffie-Hellman based protocols such as HMQV (CRYPTO 2005) and OAKE (CCS 2013). Our protocol does not rely on other cryptographic primitives—in particular, it does not use signatures—simplifying the(More)