Zhendong Zhang

Learn More
Methylenetetrahydrofolate reductase (MTHFR) catalyzes the metabolism of folate and nucleotides needed for DNA synthesis and repair. Variations in MTHFR functions likely play roles in the etiology of lung cancer. The MTHFR gene has three nonsynonymous single nucleotide polymorphisms (i.e., C677T, A1298C, and G1793A) that have a minor allele frequency of >5%.(More)
OBJECTIVE To evaluate the association between genetic polymorphisms of CYP2E1 RsaI and GSTM1 and development of bladder cancer in a south-eastern Han Chinese population. METHODS We hypothesized that the CYP2E1-1019T>A and GSTM1 polymorphisms were associated with risk of bladder cancer. In a hospital-based case-control study of 202 case patients with newly(More)
High-resolution peripheral quantitative computed tomography (HR-pQCT) provides in vivo three-dimensional (3D) imaging at the distal radius and tibia and has been increasingly used to characterize cortical and trabecular bone morphology in clinical studies. In this study, we comprehensively examined the accuracy of HR-pQCT and HR-pQCT based micro finite(More)
Up to now, most of the etiological studies of lung cancer have been focused on air pollution, radiation and smoking, etc, whereas in the past decades, we had found that fungi and mycotoxins in foodstuff might play important roles in the carcinogenesis of lung cancer. Our preliminary work showed that the liquid in pickled vegetables consumed by residents of(More)
Knee osteoarthritis (OA) is a highly prevalent chronic degenerative joint disease that mainly affects the elderly population. The aim of this study was to investigate serum signature metabolites as potential biomarkers for early diagnosis of knee OA. Global serum metabolic profiles of 40 patients with knee OA and 20 healthy controls (HC) were analyzed by(More)
In power electronics drive systems, dead time is used to prevent shoot-through over power devices. However, dead time can lead to distortion of ac output voltages and currents. Various compensation methods have been proposed to overcome this drawback. However, most strategies assume the power switches as ideal switches and the transition from ON to OFF or(More)
A simplified transient model of the Doubly Fed Induction Generator (DFIG) is used to investigate the effects when the voltage sags impose to the DFIG generation system. It is identified that the symmetrical transient voltage sag creates a DC component in the magnetic field which causes over currents in both the stator and rotor windings. The characteristics(More)
Ensuring histocompatibility in the tissue engineering of bones is a complex issue. The aim of this study was to observe the feasibility of chitosan-β-tricalcium phosphate composite in repairing limb bone defects, and to evaluate the therapeutic effects on osteogenesis. Beagle mesenchymal stem cells (MSCs) were divided into an experimental group that was(More)
The electronic fuel injector (EFI) is indispensable for real-timely controlling on the mixture ratio of a gasoline engine. With the speed of the engine is higher, there are stronger and stronger requirements for high dynamic performance of the EFI to satisfy with the limitation on fuel consuming and exhaust emission. In this study the dynamic working(More)
Narrowed intervertebral disc (IVD) space is a characteristic of IVD degeneration. EP sclerosis is associated with IVD, however the pathogenesis of EP hypertrophy is poorly understood. Here, we employed two spine instability mouse models to investigate temporal and spatial EP changes associated with IVD volume, considering them as a functional unit. We found(More)