Zhen-xiang Yao

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BACKGROUND Hepatocellular carcinoma (HCC) is one of the most common malignancies in China. The long-term survival rate of patients with HCC after prevention and management remains unsatisfactory. In order to provide a novel strategy to cure HCC, we investigated the effects of antisense oligonucleotides of PKC-alpha on proliferation and apoptosis of human(More)
OBJECTIVE To investigate the expressions of Cyclooxygenase-2 (COX-2) gene and protein in breast cancer, and understand its clinical significance. METHODS Reverse transcription-PCR, immunohistochemistry were used to assess the expression of COX-2 in 30 cancerous tissues, paired tissues adjacent to breast cancers and 6 normal tissues far from neoplasm. (More)
AIM To evaluate the effect of tumor necrosis factor (TNF), endothelin (ET) and nitric oxide (NO) on hyperdynamic circulation (HC) of rats with acute and chronic portal hypertension (PHT). METHODS Chronic portal hypertension was induced in Wistar rats by injection of carbon tetrachloride. After two weeks of cirrhosis formation, L-NMMA (25 mg/kg) was(More)
Acute hemorrhagic necrotizing pancreatitis (AHNP) was induced by introduct retrograde injection of the autologous bile in canine. The cryoprobe was under the influence of temperature ranging from -160C to -190C for fifteen to eighteen seconds, and the frozen areas were about 80% surface of pancreas. Cryotherapy of AHNP strongly inhibited the development of(More)
OBJECTIVE To study the effect of interleukin (IL)-18 ASPODN on regeneration of allogeneic partial liver graft in rats. METHODS Ninety donor SD rats and ninety recipient LEW rats were randomly divided into 3 groups: 50% partial liver transplantation group (PLT group); PLT+IL-18 antisense phosphorothioate oligodeoxynucleotide (ASPODN) treatment group (IL-18(More)
OBJECTIVE To investigate the killing effect of cytotoxic T lymphocytes (CTLs) induced with heat shock protein-peptide complexes (HSP-PC70) derived from tumor cells. METHODS Cell culture, flow cytometric analysis, affinity chromatography for protein extraction and purification, SDS-PAGE, Western blotting, CTL induction and expansion, and LDH release were(More)
Samples of serum and PBMC were collected at the same time from 42 pediatric patients with idiopathic nephrotic syndrome (INS) and 28 age-matched healthy individuals. The level of IgE in serum was detected and IL4 in supernatant of PHA-activated PBMC assayed by sandwich ELISA. The level of IL4 and IgE in healthy individuals was 400-500 pg/ml and 50-100 U/ml(More)
OBJECTIVE To study the effect of nimesulide (NIM) on the tumorigenesis of mammary tumors induced by dimethylbenzoic acid (DMBA), and to investigate possible mechanisms of NIM against tumors. METHODS The studied rats were randomly divided into four groups: experimental control group, NIM group, diet and drug of NIM control group. The incidence of mammary(More)
OBJECTIVE To further study the antitumor effects of TAM and somatostatin (SST) analog octreotide (OCT) in vivo. METHODS Eight weeks following dimethylbenzanthracene (DMBA, a single dose 100 mg/kg by subcutaneous injection) administration, 96 Wistar rats were randomly divided into four groups: control group, OCT (100 microg/kg bid for 14 weeks by(More)
AIM To investigate functional change of dendritic cells (DCs) derived from allogeneic partial liver graft undergoing acute rejection in rats. METHODS Allogeneic (SD rat to LEW rat) whole and 50 % partial liver transplantation were performed. DCs from liver grafts 0 hr and 4 days after transplantation were isolated and propagated in the presence of GM-CSF(More)
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