Zhen-hai Wang

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There is an increasing prevalence of Alzheimer's disease (AD), which has become a public health issue. However, the underlying mechanisms for the pathogenesis of AD are not fully understood, and the current therapeutic drugs cannot produce acceptable efficacy in AD patients. Previous animal studies have shown that coffee (Coff), caffeine (Caff), and(More)
—A Ku band six-bit phase shifter is presented in this work. The developed phase shifter consists of four bits realized as periodically loaded-line and two bits based on novel switched-line with loaded-line. A 71Ω line impedance is chosen for the main transmission line in order to reduce the diode loss. Every bit has special tuning elements for the fine(More)
—This letter presents a compact low temperature co-fired ceramic (LTCC) receiver front-end module integrating 9 building blocks. The receiver is a twice-frequency-conversion front-end module with image rejection, works at X-band, consists of an X-band embedded image rejection band-pass filter (BPF), an L-band multilayer image rejection quasi-ellipitc BPF,(More)
Parkinson’s disease is a neurodegenerative disorder characterized by mitochondrial dysfunction and oxidative stress. It is usually accompanied by an imbalance in mitochondrial dynamics and changes in mitochondrial morphology that are associated with impaired function. The objectives of this study were to identify the effects of rotenone, a drug known to(More)
Ventilator-associated pneumonia (VAP) is a life-threatening disease that is associated with high rates of morbidity and likely mortality, placing a heavy burden on an individual and society. Currently available diagnostic and therapeutic approaches for VAP treatment are limited, and the prognosis of VAP is poor. The present study aimed to reveal and(More)
Both wild-type and mutated beta-amyloid (Aβ) peptides can elicit an immune response when delivered subcutaneously. However, only mutated forms of Aβ can sensitize dendritic cells when administered intravenously or intraperitoneally. To understand the role of mutation and delivery routes in creating immune responses, and the function of dendritic cells as(More)
Preladenant is an orally administered adenosine2A (A2A) receptor antagonist in phase III development for Parkinson’s disease treatment. This thorough QT/QTc study evaluated its potential effects on cardiac repolarization. This was a randomized, double-blind, positive- and placebo-controlled, four-period crossover study performed under steady-state exposure(More)
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