Zhen Zhen Guo

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An increased lipid peroxides and a decreased production of prostacyclin have been shown in advanced atherosclerotic lesions and plasma. Our purpose was to determine whether the similar findings could be observed in cultured endothelial cells, and whether antioxidants could protect the cell against peroxide injury. In these experiments we have used bovine(More)
Rabbits fed an atherogenic diet for 60 days resulted in high levels of plasma lipid peroxides as well as extreme hypercholesterolemia. Both levels stayed high until 35 days after the atherogenic diet stopped. At the same time, plasma PGI2 level was remarkably decreased while TXA2 and platelet aggregability were increased. Atherosclerotic aortas contain high(More)
We have previously shown a negative correlation between lipid peroxide levels and prostacyclin synthesis in plasma and artery of the atherosclerotic rabbit. Here we compare the arterial lipid peroxide content, glutathione peroxidase activity, and prostacyclin and thromboxane production in response to exogenous arachidonic acid stimulation, and the cell(More)
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