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Total synthesis of brevetoxin A
The convergent synthesis reported here renders this scarce neurotoxin synthetically available and, more importantly, allows the design and synthesis of analogues for further biochemical studies.
Copper-free sonogashira coupling reaction with PdCl2 in water under aerobic conditions.
- B. Liang, M. Dai, Jia-Hua Chen, Zhen Yang
- Chemistry, BiologyThe Journal of organic chemistry
- 7 January 2005
A mild protocol for the copper-free Sonogashira coupling of aryl iodides with terminal acetylenes in water under aerobic conditions has been developed and good to excellent yields are reported.
Total synthesis of wedelolactone.
- Chuang‐Chuang Li, Z. Xie, Yan Zhang, J. Chen, Zhen Yang
- ChemistryThe Journal of organic chemistry
- 30 September 2003
The total synthesis of wedelolactone, a naturally occurring direct inhibitor of IKK complex that can suppress LPS-induced caspase-11 expression, using a convergent synthetic approach, is described.…
Total syntheses of drimane-type sesquiterpenoids enabled by a gold-catalyzed tandem reaction.
A unified strategy toward the stereoselective total syntheses of C-15 oxygenated drimane-type sesquiterpenoids and their analogues is achieved and provided the natural products kuehneromycin A, antrocin, anhydromarasmone, and marasmene as a proof-of-concept study.
Total synthesis of methyl protodioscin: a potent agent with antitumor activity.
Methyl protodioscin, otherwise known as 3-O-rhamnopyranosyl, has been synthesized for the first time from diosgenin through nine steps in an overall yield of 7.8%.
Asymmetric total synthesis of (-)-lingzhiol via a Rh-catalysed [3+2] cycloaddition.
An efficient [3+2] cycloaddition reaction between an enal and an alleno rhodium species, which was generated in situ from the corresponding enynol via a retro metal-propargylation reaction, to give bicyclic systems bearing two quaternary atoms at their bridgehead positions is reported.
Total Synthesis of Taxol. 3. Formation of Taxol's ABC Ring Skeleton
Concise synthesis of isoquinoline via the Ugi and Heck reactions.
[reaction: see text] Two types of isoquinoline scaffolds were successfully constructed in a combinatorial format via the Ugi four-component reaction and the Pd-catalyzed intramolecular Heck reaction,…
A Concise Synthesis of Presilphiperfolane Core through a Tandem TMTU-Co-Catalyzed Pauson-Khand Reaction and a 6π Electrocyclization Reaction (TMTU=Tetramethyl Thiourea).
- Zichun Zhang, Yuan-He Li, D. Zhao, Yingdong He, Jianxian Gong, Zhen Yang
- 26 January 2017
A tandem reaction comprising Co-TMTU (tetramethyl thiourea)-catalyzed Pauson-Khand (PK) and 6π-electrocyclization reactions for the formation of the highly strained core of presilphiperfolanols is reported.
Tunable and chemoselective syntheses of dihydroisobenzofurans and indanones via rhodium-catalyzed tandem reactions of 2-triazole-benzaldehydes and 2-triazole-alkylaryl ketones.
Two novel rhodium(II)-catalyzed tandem reactions were developed for the synthesis of dihydroisobenzofuran and indanone derivatives from 2-triazole-benzaldehydes and 2-Triazoles-alkylaryl ketones and obtained in good yields with high regioselectivities.